Macrophages in skin wounds: functions and therapeutic potential

SL Sim, S Kumari, S Kaur, K Khosrotehrani - Biomolecules, 2022 - mdpi.com
Macrophages regulate cutaneous wound healing by immune surveillance, tissue repair and
remodelling. The depletion of dermal macrophages during the early and middle stages of …

Immune modulation of hair follicle regeneration

W Rahmani, S Sinha, J Biernaskie - NPJ Regenerative medicine, 2020 - nature.com
The mammalian hair follicle undergoes repeated bouts of regeneration orchestrated by a
variety of hair follicle stem cells. The last decade has witnessed the emergence of the …

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

J Krivanek, RA Soldatov, ME Kastriti… - Nature …, 2020 - nature.com
Understanding cell types and mechanisms of dental growth is essential for reconstruction
and engineering of teeth. Therefore, we investigated cellular composition of growing and …

Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis

S Kaczanowska, DW Beury, V Gopalan, AK Tycko… - Cell, 2021 - cell.com
Metastasis is the leading cause of cancer-related deaths, and greater knowledge of the
metastatic microenvironment is necessary to effectively target this process …

Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche

Z Liu, X Hu, Y Liang, J Yu, H Li, MN Shokhirev… - Nature …, 2022 - nature.com
Maintenance of tissue homeostasis is dependent on the communication between stem cells
and supporting cells in the same niche. Regulatory T cells (Treg cells) are emerging as a …

Reprograming the immune niche for skin tissue regeneration–from cellular mechanisms to biomaterials applications

R Mu, SC de Souza, Z Liao, L Dong, C Wang - Advanced Drug Delivery …, 2022 - Elsevier
Despite the rapid development of therapeutic approaches for skin repair, chronic wounds
such as diabetic foot ulcers remain an unaddressed problem that affects millions of people …

The origins and non-canonical functions of macrophages in development and regeneration

M Theret, R Mounier, F Rossi - Development, 2019 - journals.biologists.com
The discovery of new non-canonical (ie non-innate immune) functions of macrophages has
been a recurring theme over the past 20 years. Indeed, it has emerged that macrophages …

Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis

KN Li, T Tumbar - The EMBO Journal, 2021 - embopress.org
Stem cells are the essential source of building blocks for tissue homeostasis and
regeneration. Their behavior is dictated by both cell‐intrinsic cues and extrinsic cues from …

Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

G Yang, H Chen, Q Chen, J Qiu, M Qahar, Z Fan… - Inflammation and …, 2023 - Springer
Abstract Background The hair follicles (HFs) are barely regenerated after loss in injuries in
mammals as well as in human beings. Recent studies have shown that the regenerative …

The mutual regulation between γδ T cells and macrophages during wound healing

W Hu, X Zhang, H Sheng, Z Liu, Y Chen… - Journal of leukocyte …, 2024 - academic.oup.com
Macrophages are the main cells shaping the local microenvironment during wound healing.
As the prime T cells in the skin, γδ T cells participate in regulating microenvironment …