Increasingly vitamin D deficiency is being associated with a number of psychiatric
conditions. In particular for disorders with a developmental basis, such as autistic spectrum …

Solid tumours are an enormous cancer burden and a major therapeutic challenge. The
cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for …

Some tissue types give rise to human cancers millions of times more often than other tissue
types. Although this has been recognized for more than a century, it has never been …

Sphere-forming assays have been widely used to retrospectively identify stem cells based
on their reported capacity to evaluate self-renewal and differentiation at the single-cell level …

Background Tumorigenic breast cancer cells that express high levels of CD44 and low or
undetectable levels of CD24 (CD44>/CD24>/low) may be resistant to chemotherapy and …

Human brain tumors appear to have a hierarchical cellular organization suggestive of a
stem cell foundation. In vitro expansion of the putative cancer stem cells as stable cell lines …

Several distinct cell types in the adult central nervous system have been suggested to act as
stem or progenitor cells generating new cells under physiological or pathological conditions …

Cancer Stem Cells (CSCs) are a sub-population of cells, identified in most tumors,
responsible for the initiation, recurrence, metastatic potential, and resistance of different …

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal
and differentiation. In order to better understand the contribution of substrate stiffness to …

Glial fibrillary acidic protein (GFAP)-positive astrocytes (type B cells) in the subventricular
zone (SVZ) generate large numbers of new neurons in the adult brain. SVZ stem cells can …