Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the NAD
salvage pathway of mammalian cells and is overexpressed in numerous types of cancers …

Nicotinamide adenine dinucleotide (NAD) is a cofactor of many enzymatic reactions as well
as being a substrate for a number of NAD-consuming enzymes (eg, PARPS, sirtuins, etc) …

Highlights•NAMPT is overexpressed in cancers, associating with a poor prognosis and
tumor progression.•Extensive efforts have been made to improve efficacy and safety of early …

Tumor cells have increased requirements for NAD+. Thus, many cancers exhibit an
increased reliance on NAD+ production pathways. This dependence may be exploited …

Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a
substrate for NAD-consuming enzymes, regulating cellular events such as DNA repair and …

Actively proliferating cancer cells require sufficient amount of NADH and NADPH for
biogenesis and to protect cells from the detrimental effect of reactive oxygen species. As …

Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest forms of cancer.
A major reason for this situation is the fact that these tumors are already resistant or become …

Obesity is a significant risk factor for cancer development. Within the tumor
microenvironment, adipocytes interact with cancer cells, immune cells, fibroblasts and …

Metabolic rewiring is the result of the increasing demands and proliferation of cancer cells,
leading to changes in the biological activities and responses to treatment of cancer cells …

The phenomenon of aging has gained widespread attention in recent times. Although
significant advances have been made to better understand aging and its related pathologies …