Base excision repair: mechanisms and impact in biology, disease, and medicine
Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic
single-base damage that appear to have minimal effects on the helix. Since its discovery in …
single-base damage that appear to have minimal effects on the helix. Since its discovery in …
Complex roles of NEIL1 and OGG1: insights gained from murine knockouts and human polymorphic variants
RS Lloyd - DNA, 2022 - mdpi.com
DNA glycosylases promote genomic stability by initiating base excision repair (BER) in both
the nuclear and mitochondrial genomes. Several of these enzymes have overlapping …
the nuclear and mitochondrial genomes. Several of these enzymes have overlapping …
[HTML][HTML] Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells
CG Neurauter, M Pannone, MML de Sousa… - Free Radical Biology …, 2024 - Elsevier
Abstract The NTHL1 and NEIL1-3 DNA glycosylases are major enzymes in the removal of
oxidative DNA base lesions, via the base excision repair (BER) pathway. It is expected that …
oxidative DNA base lesions, via the base excision repair (BER) pathway. It is expected that …
CHD6 has poly (ADP-ribose)-and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair
L Provencher, W Nartey, PM Brownlee… - Nature …, 2025 - nature.com
To tolerate oxidative stress, cells enable DNA repair responses often sensitive to poly (ADP-
ribose)(PAR) polymerase 1 and 2 (PARP1/2) inhibition—an intervention effective against …
ribose)(PAR) polymerase 1 and 2 (PARP1/2) inhibition—an intervention effective against …
Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice
FS Mueller, R Amport, T Notter, SM Schalbetter, HY Lin… - BMC biology, 2022 - Springer
Background Neuropsychiatric disorders, such as schizophrenia (SZ) and autism spectrum
disorder (ASD), are common, multi-factorial and multi-symptomatic disorders. Ample …
disorder (ASD), are common, multi-factorial and multi-symptomatic disorders. Ample …
Genetic determinants of coping, resilience and self-esteem in schizophrenia suggest a primary role for social factors and hippocampal neurogenesis
F Mazzarotto, P Monteleone, A Minelli, S Mattevi… - Psychiatry …, 2024 - Elsevier
Schizophrenia is a severe psychiatric disorder, associated with a reduction in life
expectancy of 15–20 years. Available treatments are at least partially effective in most …
expectancy of 15–20 years. Available treatments are at least partially effective in most …
[HTML][HTML] Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory
DL Bordin, K Grooms, NP Montaldo, SLF Martin… - DNA repair, 2024 - Elsevier
Neurodevelopment is a tightly coordinated process, during which the genome is exposed to
spectra of endogenous agents at different stages of differentiation. Emerging evidence …
spectra of endogenous agents at different stages of differentiation. Emerging evidence …
Cognitive Function Is Associated with the Genetically Determined Efficiency of DNA Repair Mechanisms
Several modifiable risk factors for neurodegeneration and dementia have been identified,
although individuals vary in their vulnerability despite a similar risk of exposure. This …
although individuals vary in their vulnerability despite a similar risk of exposure. This …