[HTML][HTML] Recent Advances in Ocular Drug Delivery: Insights into Lyotropic Liquid Crystals

S Adwan, M Qasmieh, F Al-Akayleh, ASA Ali Agha - Pharmaceuticals, 2024 - mdpi.com
Background/Objectives: This review examines the evolution of lyotropic liquid crystals
(LLCs) in ocular drug delivery, focusing on their ability to address the challenges associated …

Novel therapeutic deep eutectic system for the enhancement of ketoconazole antifungal activity and transdermal permeability

F Al-Akayleh, B Alkhawaja, N Al-Zoubi… - Journal of Molecular …, 2024 - Elsevier
In this study, we reported the investigation of a novel therapeutic deep eutectic system
(THEDES) formed between capric acid (CA) and ketoconazole (KCZ) to enhance the …

Development, characterization, and ex vivo permeation assessment of diclofenac diethylamine deep eutectic systems across human skin

L Al-Mawla, F Al-Akayleh, S Daadoue… - Journal of …, 2023 - Springer
Purpose The primary aim of this study is to introduce Therapeutic Deep Eutectic Systems
(THEDES) as a novel, green, and biocompatible solvent system for the delivery of diclofenac …

Structural insights into novel therapeutic deep eutectic systems with capric acid using 1D, 2D NMR and DSC techniques with superior gut permeability

B Alkhawaja, F Al-Akayleh, J Nasereddin, M Kamran… - RSC …, 2024 - pubs.rsc.org
Therapeutic deep eutectic solvents (THEDSs) are the best exemplification of green
alternative formulations of active pharmaceutical ingredients (APIs) that offer superlative …

[HTML][HTML] Antioxidant activity and UHPLC-MS/MS characterization of polyphenol and nicotine content in Nicotiana glauca leaf extracts: a comparative study of …

R Issa, F Al-Akayleh, L Alnsour, TR Al-Sammarraie… - Plants, 2024 - mdpi.com
The leaves of Nicotiana glauca (N. glauca; Solanaceae) plant are a known, major human
health concern. This study investigated the antioxidant activity and polyphenols composition …

Deep Eutectic System-Based Liquisolid Nanoparticles as Drug Delivery System of Curcumin for In-Vitro Colon Cancer Cells

A Nakaweh, F Al-Akayleh, M Al-Remawi… - Journal of …, 2024 - Springer
Purpose This study aims to improve curcumin's solubility and anti-cancer effectiveness by
utilizing deep eutectic solvents (DES)-based liquisolid nanoparticles. This study aims to …

Levofloxacin–fatty Acid systems: dual enhancement through deep eutectic formation and solubilization for Pharmaceutical potential and antibacterial activity

B Alkhawaja, F Al-Akayleh, J Nasereddin, SA Malek… - AAPS …, 2023 - Springer
Fatty acids, including medium-chain saturated and polyunsaturated fatty acids, are known
for their broad health benefits, including antimicrobial activity. Through their green …

Development of three-layer microneedle system for controlled and sustained release of Levonorgestrel: A pioneering approach to long-term contraceptive delivery

AD Permana, AYR Aziz, NRA Ilyas, APD Putri… - International Journal of …, 2025 - Elsevier
The increasing prevalence of unintended pregnancies, a persistent issue affecting public
health and hindering progress towards the Sustainable Development Goals (SDGs) …

[HTML][HTML] Exploring Deep Eutectic Solvents as Pharmaceutical Excipients: Enhancing the Solubility of Ibuprofen and Mefenamic Acid

MA Nica, V Anuța, CA Nicolae, L Popa… - …, 2024 - pmc.ncbi.nlm.nih.gov
Objectives: The study explores the potential of various deep eutectic solvents (DESs) to
serve as drug delivery systems and pharmaceutical excipients. The research focuses on two …