From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells

A Giordano, U Galderisi… - Journal of cellular …, 2007 - Wiley Online Library
Abstract Mesenchymal Stem Cells (MSCs) are non‐hematopoietic multi‐potent stem‐like
cells that are capable of differentiating into both mesenchymal and non‐mesenchymal …

[HTML][HTML] Mesenchymal stem cells: paradoxes of passaging

EH Javazon, KJ Beggs, AW Flake - Experimental hematology, 2004 - Elsevier
The field of stem cell biology continues to evolve with the ongoing characterization of
multiple types of stem cells with their inherent potential for experimental and clinical …

[HTML][HTML] Cardiomyocytes can be generated from marrow stromal cells in vitro

S Makino, K Fukuda, S Miyoshi… - The Journal of …, 1999 - Am Soc Clin Investig
We have isolated a cardiomyogenic cell line (CMG) from murine bone marrow stromal cells.
Stromal cells were immortalized, treated with 5-azacytidine, and spontaneously beating cells …

[HTML][HTML] Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes

I Kehat, D Kenyagin-Karsenti, M Snir… - The Journal of …, 2001 - Am Soc Clin Investig
The study of human cardiac tissue development is hampered by the lack of a suitable in vitro
model. We describe the phenotypic properties of cardiomyocytes derived from human …

Systemic delivery of bone marrow–derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution

IM Barbash, P Chouraqui, J Baron, MS Feinberg… - Circulation, 2003 - Am Heart Assoc
Background—Systemic delivery of bone marrow–derived mesenchymal stem cells (BM-
MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat …

Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans

BE Strauer, M Brehm, T Zeus, M Köstering… - Circulation, 2002 - Am Heart Assoc
Background—Experimental data suggest that bone marrow–derived cells may contribute to
the healing of myocardial infarction (MI). For this reason, we analyzed 10 patients who were …

Mobilized bone marrow cells repair the infarcted heart, improving function and survival

D Orlic, J Kajstura, S Chimenti… - Proceedings of the …, 2001 - National Acad Sciences
Attempts to repair myocardial infarcts by transplanting cardiomyocytes or skeletal myoblasts
have failed to reconstitute healthy myocardium and coronary vessels integrated structurally …

[HTML][HTML] Evidence that human cardiac myocytes divide after myocardial infarction

AP Beltrami, K Urbanek, J Kajstura… - … England Journal of …, 2001 - Mass Medical Soc
Background The scarring of the heart that results from myocardial infarction has been
interpreted as evidence that the heart is composed of myocytes that are unable to divide …

Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction

S Chen, W Fang, F Ye, YH Liu, J Qian, S Shan… - The American journal of …, 2004 - Elsevier
Sixty-nine patients who underwent primary percutaneous coronary intervention within 12
hours after onset of acute myocardial infarction were randomized to receive intracoronary …

Autologous transplantation of bone marrow cells improves damaged heart function

S Tomita, RK Li, RD Weisel, DAG Mickle, EJ Kim… - Circulation, 1999 - Am Heart Assoc
Background—Autologous bone marrow cells (BMCs) transplanted into ventricular scar
tissue may differentiate into cardiomyocytes and restore myocardial function. This study …