Integrating ion mobility and imaging mass spectrometry for comprehensive analysis of biological tissues: A brief review and perspective

ES Rivera, KV Djambazova… - Journal of Mass …, 2020 - Wiley Online Library
Imaging mass spectrometry (IMS) technologies are capable of mapping a wide array of
biomolecules in diverse cellular and tissue environments. IMS has emerged as an essential …

Comprehensive LESA mass spectrometry imaging of intact proteins by integration of cylindrical FAIMS

RL Griffiths, JW Hughes, SE Abbatiello… - Analytical …, 2020 - ACS Publications
The benefits of high field asymmetric waveform ion mobility spectrometry (FAIMS) for mass
spectrometry imaging of intact proteins in thin tissue sections have been demonstrated …

[HTML][HTML] Glucocorticoids-based prodrug design: current strategies and research progress

H Liu, M Ji, P Xiao, J Gou, T Yin, H He, X Tang… - Asian Journal of …, 2024 - Elsevier
Attributing to their broad pharmacological effects encompassing anti-inflammation, antitoxin,
and immunosuppression, glucocorticoids (GCs) are extensively utilized in the clinic for the …

Quantitative analysis of soluble costimulatory molecules as potential diagnostic biomarkers for rheumatoid arthritis using LC-MS/MS in MRM mode

AK Malkawi, RM Nimer, M Almogren, A Masood… - Clinica chimica acta, 2023 - Elsevier
Background and aims Rheumatoid arthritis (RA) is a chronic autoimmune disease. RA-
induced immunological responses are coordinated by T-cell stimulation. The costimulatory …

Proteomics profiling of osteoporosis and osteopenia patients and associated network analysis

MM Al-Ansari, SM Aleidi, A Masood… - International Journal of …, 2022 - mdpi.com
Bone mass reduction due to an imbalance in osteogenesis and osteolysis is characterized
by low bone mineral density (LBMD) and is clinically classified as osteopenia (ON) or …

Dexamethasone-induced perturbations in tissue metabolomics revealed by chemical isotope labeling LC-MS analysis

LA Dahabiyeh, AK Malkawi, X Wang, D Colak… - Metabolites, 2020 - mdpi.com
Dexamethasone (Dex) is a synthetic glucocorticoid (GC) drug commonly used clinically for
the treatment of several inflammatory and immune-mediated diseases. Despite its broad …

Tissue-based proteomic profiling in patients with hyperplasia and endometrial cancer

K Akkour, IO Alanazi, AA Alfadda, H Alhalal, A Masood… - Cells, 2022 - mdpi.com
Uterine cancers are among the most prevalent gynecological malignancies, and
endometrial cancer (EC) is the most common in this group. This study used tissue-based …

Morphological and histological abnormalities of the neotropical toad, Rhinella arenarum (Anura: Bufonidae) larvae exposed to dexamethasone

AP Cuzziol Boccioni, PM Peltzer… - … Science and Health …, 2020 - Taylor & Francis
Dexamethasone (DEX) is a glucocorticoid highly effective as an anti-inflammatory,
immunosuppressant and decongestant drug. In the present study, a preliminary acute …

Tissue lipidomic alterations induced by prolonged dexamethasone treatment

AZ Buzatto, A Malkawi, EM Sabi… - Journal of proteome …, 2021 - ACS Publications
Dexamethasone is a synthetic glucocorticoid medication vastly used to treat abnormal
immune responses and inflammation. Although the medication is well-established in the …

Quantitative proteomics analysis for the identification of differential protein expression in calf muscles between young and old SD rats using mass spectrometry

JA Kim, P Vetrivel, SM Kim, SE Ha, HH Kim… - ACS …, 2021 - ACS Publications
Aging is associated with loss of muscle mass and strength that leads to a condition termed
sarcopenia. Impaired conditions, morbidity, and malnutrition are the factors of devaluation of …