BACKGROUND The core of the mammalian circadian clock mechanism is a time-delayed
transcription-translation feedback loop (TTFL), which influences the transcription and …

In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …

Background Combating viral hepatitis is part of the UN Sustainable Development Goals
(SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector …

Background Colorectal cancer is the third leading cause of cancer deaths worldwide. Given
the recent increasing trends in colorectal cancer incidence globally, up-to-date information …

The importance of circadian biology has rarely been considered in pre-clinical studies, and
even more when translating to the bedside. Circadian biology is becoming a critical factor for …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …

Timing chemotherapy on the basis of the body's intrinsic circadian clock—ie,
chronomodulated chemotherapy—might improve efficacy and reduce treatment toxicity. This …

Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …

The circadian system is responsible for internal functions and regulation of the organism
according to environmental cues (zeitgebers). Circadian rhythm dysregulation or …