Non-invasive kinetic modelling approaches for quantitative analysis of brain PET studies
CWJ Van Der Weijden, P Mossel, AL Bartels… - European Journal of …, 2023 - Springer
Pharmacokinetic modelling with arterial sampling is the gold standard for analysing dynamic
PET data of the brain. However, the invasive character of arterial sampling prevents its …
PET data of the brain. However, the invasive character of arterial sampling prevents its …
The rise of synaptic density PET imaging
Many neurological disorders are related to synaptic loss or pathologies. Before the boom of
positrons emission tomography (PET) imaging of synapses, synaptic quantification could …
positrons emission tomography (PET) imaging of synapses, synaptic quantification could …
In vivo imaging of synaptic loss in Alzheimer's disease with [18F] UCB-H positron emission tomography
Purpose Loss of brain synapses is an early pathological feature of Alzheimer's disease. The
current study assessed synaptic loss in vivo with positron emission tomography and an 18F …
current study assessed synaptic loss in vivo with positron emission tomography and an 18F …
Test–retest reproducibility of [11C]PBR28 binding to TSPO in healthy control subjects
K Collste, A Forsberg, A Varrone, N Amini… - European journal of …, 2016 - Springer
Abstract Purpose The PET radioligand [11 C] PBR28 binds to the translocator protein
(TSPO), a marker of brain immune activation. We examined the reproducibility of [11 C] …
(TSPO), a marker of brain immune activation. We examined the reproducibility of [11 C] …
Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB‐H
Introduction Brain distribution of synaptic vesicle protein 2A was measured with fluorine‐18
UCB‐H ([18F] UCB‐H) and positron emission tomography (PET). Methods Images of …
UCB‐H ([18F] UCB‐H) and positron emission tomography (PET). Methods Images of …
In vivo exploration of synaptic projections in frontotemporal dementia
The purpose of this exploratory research is to provide data on synaptopathy in the
behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with probable …
behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with probable …
Learning representations in Bayesian Confidence Propagation neural networks
NB Ravichandran, A Lansner… - 2020 International Joint …, 2020 - ieeexplore.ieee.org
Unsupervised learning of hierarchical representations has been one of the most vibrant
research directions in deep learning during recent years. In this work we study biologically …
research directions in deep learning during recent years. In this work we study biologically …
[HTML][HTML] Investigation of image-derived input functions for non-invasive quantification of myelin density using [11C] MeDAS PET
CWJ van der Weijden, A van der Hoorn, Y Wang… - Neuroimage, 2022 - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating disease. Current treatments are
focussed on immune suppression to modulate pathogenic activity that causes myelin …
focussed on immune suppression to modulate pathogenic activity that causes myelin …
Regularization of images
The present disclosure is directed to iterative regularized reconstruction methods. In certain
embodiments, the methods incorporate locally-weighted total variation denoising to …
embodiments, the methods incorporate locally-weighted total variation denoising to …
Non-invasive estimation of [11C] PBR28 binding potential
Abstract [11 C] PBR28 is a PET radioligand used to estimate densities of the 18 kDa
translocator protein (TSPO) in vivo. Since there is no suitable reference region, arterial blood …
translocator protein (TSPO) in vivo. Since there is no suitable reference region, arterial blood …