IL-6 induces periostin production in human ACL remnants: a possible mechanism causing post-traumatic osteoarthritis

TH Tseng, CL Chen, CH Chang, JH Wang… - Journal of Orthopaedic …, 2023 - Springer
Abstract Objective Perostin (POSTN) and IL-6 consistently elevated after ACL injury, and
ACL has been proposed as the major source of POSTN. However, there is a lack of …

Abnormal basement membrane results in increased keratinocyte-derived periostin expression in psoriasis similar to wound healing

LB Flink, A Ghaffarinia, BT Papp, Á Varga, AI Vigh… - Scientific Reports, 2023 - nature.com
The psoriatic skin resembles wound healing, and it shows abnormalities at the basement
membrane (BM), also in the non-lesional skin. Fibroblast-derived dermal periostin has well …

Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis

QB Lu, X Fu, Y Liu, ZC Wang, SY Liu, YC Li… - Cellular & Molecular …, 2023 - Springer
Background Periostin is an extracellular matrix protein that plays a critical role in cell fate
determination and tissue remodeling, but the underlying role and mechanism of periostin in …

N6-methyladenosine-mediated upregulation of LINC00520 accelerates breast cancer progression via regulating miR-577/POSTN axis and downstream ILK/AKT …

Y Guo, L Feng - Archives of Biochemistry and Biophysics, 2022 - Elsevier
Various lncRNAs have been reported to be closely associated with cancer initiation and
progression in breast cancer (BC), including LINC00520. However, the role and underlying …

Role of periostin and nuclear factor-κb interplay in the development of diabetic nephropathy

L Abbad, N Prakoura, A Michon, R Chalghoumi… - Cells, 2022 - mdpi.com
Diabetic nephropathy (DN) remains the most common reason for end-stage renal disease
and a leading cause of kidney replacement therapy. Multifactorial pathophysiological …

Fibroblast growth factor 5 overexpression ameliorated lipopolysaccharide-induced apoptosis of hepatocytes through regulation of the phosphoinositide-3-kinase …

S Cui, Y Li, X Zhang, B Wu, M Li, J Gao… - Chinese medical …, 2022 - journals.lww.com
Background: Sepsis is a systemic inflammatory syndrome induced by several infectious
agents. Multiple organs are affected by sepsis, including the liver, which plays an important …

[HTML][HTML] CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer

X Yuan, X Hao, HL Chan, N Zhao, DA Pedroza… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
Tumor-associated neutrophils (TANs) have been shown to promote immunosuppression
and tumor progression, and a high TAN frequency predicts poor prognosis in triple-negative …

Increased expression of POSTN predicts poor prognosis: a potential therapeutic target for gastric cancer

S Lu, L Peng, F Ma, J Chai, Y Hua, W Yang… - Journal of …, 2023 - Elsevier
Background Periostin (POSTN) is involved in many biological processes and is associated
with the occurrence and development of several cancers, while its role in gastric cancer is …

Engineering extracellular vesicles derived from lemons for delivering chemotherapeutic drug employing periostin targeting

Z Jamshidi, S Dehghani, MA Nameghi… - Journal of Drug Delivery …, 2024 - Elsevier
Drug administration methods aim to reduce adverse effects and enhance the effectiveness
of chemotherapy medications. Extracellular vesicles (EVs) have shown outstanding ability in …

Periostin as a blood biomarker of muscle cell fibrosis, cardiomyopathy and disease severity in myotonic dystrophy type 1

CDL Nguyen, AC Jimenez-Moreno, M Merker… - Journal of …, 2023 - Springer
Background and purpose Myotonic dystrophy type 1 (DM1) is the most common form of adult-
onset muscular dystrophy and is caused by an repeat expansion [r (CUG) exp] located in the …