Quality control in the endoplasmic reticulum: crosstalk between ERAD and UPR pathways
Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …
response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for …
ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum
F Reggiori, M Molinari - Physiological reviews, 2022 - journals.physiology.org
ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …
Novel Alzheimer disease risk loci and pathways in African American individuals using the African genome resources panel: a meta-analysis
Importance Compared with non-Hispanic White individuals, African American individuals
from the same community are approximately twice as likely to develop Alzheimer disease …
from the same community are approximately twice as likely to develop Alzheimer disease …
Glycosylation-directed quality control of protein folding
C Xu, DTW Ng - Nature reviews Molecular cell biology, 2015 - nature.com
Membrane-bound and soluble proteins of the secretory pathway are commonly glycosylated
in the endoplasmic reticulum. These adducts have many biological functions, including …
in the endoplasmic reticulum. These adducts have many biological functions, including …
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration
The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …
essential for cellular homeostasis, development, and stress responsiveness. In response to …
α1-Antitrypsin deficiency
Abstract α1-Antitrypsin deficiency (A1ATD) is an inherited disorder caused by mutations in
SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes …
SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes …
Road to ruin: targeting proteins for degradation in the endoplasmic reticulum
MH Smith, HL Ploegh, JS Weissman - Science, 2011 - science.org
Some nascent proteins that fold within the endoplasmic reticulum (ER) never reach their
native state. Misfolded proteins are removed from the folding machinery, dislocated from the …
native state. Misfolded proteins are removed from the folding machinery, dislocated from the …
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
AH Lee, NN Iwakoshi, LH Glimcher - Molecular and cellular biology, 2003 - Taylor & Francis
The mammalian unfolded protein response (UPR) protects the cell against the stress of
misfolded proteins in the endoplasmic reticulum (ER). We have investigated here the …
misfolded proteins in the endoplasmic reticulum (ER). We have investigated here the …
Roles of N-linked glycans in the endoplasmic reticulum
A Helenius, M Aebi - Annual review of biochemistry, 2004 - annualreviews.org
▪ Abstract From a process involved in cell wall synthesis in archaea and some bacteria, N-
linked glycosylation has evolved into the most common covalent protein modification in …
linked glycosylation has evolved into the most common covalent protein modification in …
ER stress and the unfolded protein response
M Schröder, RJ Kaufman - Mutation Research/Fundamental and Molecular …, 2005 - Elsevier
Conformational diseases are caused by mutations altering the folding pathway or final
conformation of a protein. Many conformational diseases are caused by mutations in …
conformation of a protein. Many conformational diseases are caused by mutations in …