Metabolic pathway engineering in the yeast Saccharomyces cerevisiae leads to improved
production of a wide range of compounds, ranging from ethanol (from biomass) to natural …

Selected strains of Saccharomyces cerevisiae are used for commercial bioethanol
production from cellulose and starch, but the high cost of exogenous enzymes for substrate …

Hydrogen peroxide (H2O2) sensing and signaling involves the reversible oxidation of
particular thiols on particular proteins to modulate protein function in a dynamic manner …

Opioids are the primary drugs used in Western medicine for pain management and palliative
care. Farming of opium poppies remains the sole source of these essential medicines …

Industrial polyploid yeast strains harbor numerous beneficial traits but suffer from a lack of
available auxotrophic markers for genetic manipulation. Here we demonstrated a quick and …

The biologically and commercially important terpenoids are a large and diverse class of
natural products that are targets of metabolic engineering. However, in the context of …

Adipic acid is a high-value compound used primarily as a precursor for the synthesis of
nylon, coatings, and plastics. Today it is produced mainly in chemical processes from …

Signal transduction through mitogen-activated protein kinase (MAPK) cascades is thought to
occur through the assembly of macromolecular complexes. We quantified the abundance of …

Background The branched chain alcohol isobutanol exhibits superior physicochemical
properties as an alternative biofuel. The yeast Saccharomyces cerevisiae naturally produces …

Metabolic engineering of microorganisms is an alternative and attractive route for production
of valuable terpenoids that are usually extracted from plant sources. Tanshinones are the …