Silymarin: a review on paving the way towards promising pharmacological agent

MN Akhtar, R Saeed, F Saeed, A Asghar… - … Journal of Food …, 2023 - Taylor & Francis
Advancements in the field of research and development have paved toward the use of
herbal agents to cure and control health maladies. Milk thistle (Silybum marianum L.) is one …

Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical …

M Ghodousi, H Karbasforooshan, L Arabi… - European Journal of …, 2023 - Springer
Purpose Thus far, silymarin has been examined in several studies for prevention or
treatment of various chemotherapy or radiotherapy-induced adverse reactions. In this …

[HTML][HTML] The effects of olive leaf extract on the testis, sperm quality and testicular germ cell apoptosis in male rats exposed to busulfan

SG Hakemi, F Sharififar, T Haghpanah… - … journal of fertility & …, 2019 - ncbi.nlm.nih.gov
Background Busulfan (BU) has a destructive effect on the male reproductive system. The
goal of this study was to assess the effects of olive leaf extract (OLE) as a source of …

[HTML][HTML] Utility of melatonin in mitigating ionizing radiation-induced testis injury through synergistic interdependence of its biological properties

ME Amer, AI Othman, HM Abozaid, MA El-Missiry - Biological Research, 2022 - Springer
Background Ionizing radiations (IR) have widespread useful applications in our daily life;
however, they have unfavorable effects on reproductive health. Maintaining testicular health …

[HTML][HTML] Radioprotective effects of Silymarin on the sperm parameters of NMRI mice irradiated with γ-rays

D Fatehi, M Mohammadi, B Shekarchi… - … of Photochemistry and …, 2018 - Elsevier
Free radicals and reactive oxygen species (ROS) are generated using various endogenous
systems or from external sources such as exposure to different physiochemicals. Ionizing …

[HTML][HTML] Grape seed proanthocyanidins exert a radioprotective effect on the testes and intestines through antioxidant effects and inhibition of MAPK signal pathways

H Shen, J Han, C Liu, F Cao, Y Huang - Frontiers in Medicine, 2022 - frontiersin.org
The testes and intestines are highly sensitive to ionizing radiation. Low-dose radiation can
cause infertility and enteritis. However, there is a lack of safe and efficient radioprotective …

[HTML][HTML] Evaluating the protective effect of resveratrol, Q10, and alpha-lipoic acid on radiation-induced mice spermatogenesis injury: A histopathological study

M Najafi, M Cheki, P Amini, A Javadi… - International Journal …, 2019 - ncbi.nlm.nih.gov
Background Testis is one of the most sensitive organs against the toxic effect of ionizing
radiation. Exposure to even a low dose of radiation during radiotherapy, diagnostic …

[HTML][HTML] Clinical role of silymarin in oxidative stress and infertility: A short review for pharmacy practitioners

M Zarif-Yeganeh, M Rastegarpanah - Journal of research in …, 2019 - journals.lww.com
Silymarin (SMN) as an ancient plant has various therapeutic usage in many diseases.
Almost all of its properties attributed to antioxidant and anti-inflammatory properties …

Effects of Sargassum virgatum extracts on the testicular measurements, genomic DNA and antioxidant enzymes in irradiated rats

AI Semaida, MA El-Khashab, AA Saber… - … Journal of Radiation …, 2022 - Taylor & Francis
Background Oxidative stress and reactive oxygen species (ROS) are primarily responsible
for the development of male infertility after exposure to γ-irradiation. The present work aimed …

Negative effect of feeding with high energy diets on testes and metabolic blood parameters of male Japanese quails, and positive role of milk thistle seed

S Çeribaşı, G Türk, M Özçelik, G Doğan, AO Çeribaşı… - Theriogenology, 2020 - Elsevier
In this study, it was aimed to investigate the changes in testicular tissue and cell count,
testicular oxidative stress and some metabolic blood parameters of male broiler Japanese …