Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Abstract Interleukin-6 (IL-6) is a cytokine originally identified almost 30 years ago as a B-cell
differentiation factor, capable of inducing the maturation of B cells into antibody-producing …

Almost a quarter of a century ago, interleukin-6 (IL-6) was discovered as an inflammatory
cytokine involved in B cell differentiation. Today, IL-6 is recognized to be a highly versatile …

Pain and depression are frequently comorbid disorders, but the mechanism underlying this
association is unknown. Here, we report that brain indoleamine 2, 3-dioxygenase 1 (IDO1) …

Inflammatory mechanisms both in the periphery and in the CNS are important in the
pathophysiologic processes occurring after the onset of ischemic stroke (IS). Cytokines are …

Mature retinal ganglion cells (RGCs) do not normally regenerate injured axons and undergo
apoptosis after axotomy. Inflammatory stimulation (IS) in the eye mediates neuroprotection …

Transgenic mouse lines in which a fluorescent protein is constitutively expressed under the
Thy1 gene promoter have become important models in cell biology and pathology studies of …

Autism spectrum disorder (ASD) is a neurological disorder that manifests during early
development, impacting individuals through their ways of communicating, social behaviors …

Besides its wide range of action as a proinflammatory cytokine in the immune system,
interleukin-6 (IL-6) has also attracted much attention due to its influence on the nervous …