Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …

Most acute strokes are ischemic, and subsequent neuroinflammation promotes further
damage leading to cell death but also plays a beneficial role by promoting cellular repair …

Neovascularization and vascular remodeling are functionally important for brain repair after
stroke. We show that neutrophils accumulate in the peri-infarct cortex during all stages of …

Uncontrolled inflammation is linked to poor outcomes in sepsis and wound healing, both of
which proceed through distinct inflammatory and resolution phases. Eicosanoids are a class …

Neutrophil extracellular traps (NETs) have been identified as one pathogenetic trigger in
severe COVID-19 cases and therefore well-described animal models to understand the …

Ischemic stroke is one of the main issues threatening human health worldwide, and it is also
the main cause of permanent disability in adults. Energy consumption and hypoxia after …

The microvascular endothelium serves as the major barrier that controls the transport of
blood constituents across the vessel wall. Barrier leakage occurs during infection or sterile …

Extracellular vesicles (EVs) have attracted rising interests in the cardiovascular field not only
because they serve as serological markers for circulatory disorders but also because they …

Background: Trauma patients are vulnerable to coagulopathy and inflammatory dysfunction
associated with endotheliopathy of trauma (EoT). In vitro evidence has suggested that …

Neutrophils constitute the first line of defense in human immunity and can be attracted to
inflamed and infected sites by various chemokines. As essential players in immune …