Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and
are implicated in epithelial to mesenchymal transition, cell-cycle progression …

Primary cilia are microtubule-based organelles that extend from the apical surface of most
mammalian cells, forming when the basal body (derived from the mother centriole) docks at …

DNA double-strand breaks repaired by non-homologous end joining display limited DNA
end-processing and chromosomal mobility. By contrast, double-strand breaks undergoing …

Influenza A virus (IAV) enters host cells upon binding of its hemagglutinin glycoprotein to
sialylated host cell receptors. Whereas dynamin-dependent, clathrin-mediated endocytosis …

The mechanisms that mediate the release of intracellular bacteria from cells are poorly
understood, particularly for those that live within a cellular vacuole. The release pathway of …

Macrophages serve to maintain organ homeostasis in response to challenges from injury,
inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has …

The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in
metastasis, which is the leading cause of death from cancer. Invasive cell migration requires …

Autoregulatory domains found within kinases may provide more unique targets for chemical
inhibitors than the conserved ATP-binding pocket targeted by most inhibitors. The kinase …

Using newly generated monoclonal antibodies, we have compared the distribution of β-and
γ-cytoplasmic actin in fibroblastic and epithelial cells, in which they play crucial roles during …

It is becoming increasingly clear that the fundamental capacity to undergo conformational
change in response to ligand binding is intrinsic to proteins. This property confers on …