Activation of mast cells by neuropeptides: the role of pro-inflammatory and anti-inflammatory cytokines

D Lauritano, F Mastrangelo, C D'Ovidio… - International journal of …, 2023 - mdpi.com
Mast cells (MCs) are tissue cells that are derived from bone marrow stem cells that
contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity …

[HTML][HTML] Trained immunity in type 2 immune responses

F Hartung, J Esser-von Bieren - Mucosal Immunology, 2022 - Elsevier
Immunological memory of innate immune cells, also termed “trained immunity”, allows for
cross-protection against distinct pathogens, but may also drive chronic inflammation. Recent …

Innate (learned) memory

B Al, TK Suen, K Placek, MG Netea - Journal of Allergy and Clinical …, 2023 - Elsevier
With the growing body of evidence, it is now clear that not only adaptive immune cells but
also innate immune cells can mount a more rapid and potent non-specific immune response …

Training vs. Tolerance: the yin/yang of the innate immune system

T Lajqi, N Köstlin-Gille, R Bauer, SG Zarogiannis… - Biomedicines, 2023 - mdpi.com
For almost nearly a century, memory functions have been attributed only to acquired
immune cells. Lately, this paradigm has been challenged by an increasing number of …

[HTML][HTML] Targeting mast cell activation alleviates anti-MHC I antibody and LPS-induced TRALI in mice by pharmacologically blocking the TLR3 and MAPK pathway

X Fang, T Song, L Zheng, Y Weng, F Gao, C Mo… - Biomedicine & …, 2024 - Elsevier
Transfusion-related lung injury (TRALI) poses a significant risk following blood transfusion
and remains the primary cause of transfusion-related morbidity and mortality, primarily …

[HTML][HTML] Reduced microRNA-744 expression in mast cell-derived exosomes triggers epithelial cell ferroptosis in acute respiratory distress syndrome

X Fang, F Gao, L Zheng, FS Xue, T Zhu, X Zheng - Redox Biology, 2024 - Elsevier
Acute respiratory distress syndrome (ARDS) is a critical disorder characterized by immune-
related damage to epithelial cells; however, its underlying mechanism remains elusive. This …

Emerging Role of the Mast Cell–Microbiota Crosstalk in Cutaneous Homeostasis and Immunity

CJ Bosveld, C Guth, N Limjunyawong, P Pundir - Cells, 2023 - mdpi.com
The skin presents a multifaceted microbiome, a balanced coexistence of bacteria, fungi, and
viruses. These resident microorganisms are fundamental in upholding skin health by both …

Endotoxin tolerance and trained immunity: breaking down immunological memory barriers

E López-Collazo, C Del Fresno - Frontiers in Immunology, 2024 - frontiersin.org
For decades, innate immune cells were considered unsophisticated first responders, lacking
the adaptive memory of their T and B cell counterparts. However, mounting evidence …

" Open Sesame" to the complexity of pattern recognition receptors of myeloid-derived suppressor cells in cancer

T Wang, Y Hu, S Dusi, F Qi, S Sartoris, S Ugel… - Frontiers in …, 2023 - frontiersin.org
Pattern recognition receptors are primitive sensors that arouse a preconfigured immune
response to broad stimuli, including nonself pathogen-associated and autologous damage …

Impact of Helicobacter pylori and metabolic syndrome on mast cell activation-related pathophysiology and neurodegeneration

J Kountouras, M Boziki, E Kazakos, P Theotokis… - Neurochemistry …, 2024 - Elsevier
Both Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) are highly
prevalent worldwide. The emergence of relevant research suggesting a pathogenic linkage …