Functional roles of JNK and p38 MAPK signaling in nasopharyngeal carcinoma

LJW Pua, CW Mai, FFL Chung, ASB Khoo… - International journal of …, 2022 - mdpi.com
c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members integrate signals that affect proliferation, differentiation, survival, and migration in a …

Role of licochalcone A in potential pharmacological therapy: a review

MT Li, L Xie, HM Jiang, Q Huang, RS Tong… - Frontiers in …, 2022 - frontiersin.org
Licochalcone A (LA), a useful and valuable flavonoid, is isolated from Glycyrrhiza uralensis
Fisch. ex DC. and widely used clinically in traditional Chinese medicine. We systematically …

Anticancer activity of natural and synthetic chalcones

T Constantinescu, CN Lungu - International journal of molecular sciences, 2021 - mdpi.com
Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and
inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells …

Licochalcone A: a review of its pharmacology activities and molecular mechanisms

M Liu, Y Du, D Gao - Frontiers in Pharmacology, 2024 - frontiersin.org
Licorice, derived from the root of Glycyrrhiza uralensis Fisch, is a key Traditional Chinese
Medicine known for its detoxifying, spleen-nourishing, and qi-replenishing properties …

Anti-proliferative and pro-apoptotic effects of Licochalcone A through ROS-mediated cell cycle arrest and apoptosis in human bladder cancer cells

SH Hong, HJ Cha, H Hwang-Bo, MY Kim… - International journal of …, 2019 - mdpi.com
Licochalcone A (LCA) is a chalcone that is predominantly found in the root of Glycyrrhiza
species, which is widely used as an herbal medicine. Although previous studies have …

Licochalcone A-induced apoptosis through the activation of p38MAPK pathway mediated mitochondrial pathways of apoptosis in human osteosarcoma cells in vitro …

RC Lin, SF Yang, HL Chiou, SC Hsieh, SH Wen, KH Lu… - Cells, 2019 - mdpi.com
Background: Licochalcone A (LicA) is isolated from the roots of Glycyrrhiza glabra and
possesses antitumor and anti-invasive activities against several tumor cells. However, the …

Prolonged treatment with the proteasome inhibitor MG-132 induces apoptosis in PC12 rat pheochromocytoma cells

O Tarjányi, J Haerer, M Vecsernyés, G Berta… - Scientific Reports, 2022 - nature.com
Rat pheochromocytoma (PC12) cells were treated with the proteasome inhibitor MG-132
and morphological changes were recorded. Initially, neuronal differentiation was induced …

Gossypol reduces metastasis and epithelial-mesenchymal transition by targeting protease in human cervical cancer

YS Hsieh, SC Chu, SC Huang, SH Kao… - The American Journal …, 2021 - World Scientific
Metastasis is the most prevalent cause of cancer-associated deaths amongst patients with
cervical cancer. Epithelial–mesenchymal transition (EMT) is essential for carcinogenesis …

Licochalcone C induces cell cycle G1 arrest and apoptosis in human esophageal squamous carcinoma cells by activation of the ROS/MAPK signaling pathway

AW Kwak, JS Choi, K Liu, MH Lee, YJ Jeon… - Journal of …, 2020 - Taylor & Francis
Along with changes in dietary habits and lifestyle, the incidence of esophageal cancer is
increasing around the world. Since chemotherapy for esophageal cancer has significant …

Licochalcone A suppresses the proliferation of osteosarcoma cells through autophagy and ATM-Chk2 activation

TS Shen, YK Hsu, YF Huang, HY Chen, CP Hsieh… - Molecules, 2019 - mdpi.com
Licochalcone A, a flavonoid extracted from licorice root, has been shown to exhibit broad
anti-inflammatory, anti-bacterial, anticancer, and antioxidative bioactivity. In this study, we …