Kinins are proinflammatory peptides that mediate numerous vascular and pain responses to
tissue injury. Two pharmacologically distinct kinin receptor subtypes have been identified …

Kinins are generated within inflammatory tissue microenvironments, where they exert
diverse functions, including cell proliferation, leukocyte activation, cell migration, endothelial …

Background and Purpose—Brain edema is detrimental in ischemic stroke and its treatment
options are limited. Kinins are proinflammatory peptides that are released during tissue …

We have previously reported that exogenous bradykinin activates immature dendritic cells
(DCs) via the bradykinin B 2 receptor (B 2 R), thereby stimulating adaptive immunity. In this …

Upon activation the human bradykinin B 2 receptor (B 2 R) acts as guanine nucleotide
exchange factor for the G proteins G q/11 and G i. Thereafter, it gets phosphorylated by G …

Imbalance of collagen I expression results in severe pathologies. Apart from activation by
the TGFβ-receptor/Smad pathway, control of collagen I expression remains poorly …

Bradykinin drives normal lung fibroblasts into myofibroblasts, induces fibroblast proliferation
and activates mitogen activated protein kinase pathways (MAPK) but its effects on bronchial …

Bradykinin is an important modulator of endothelial cell function and has also a powerful
cardioprotective effect. Here we report that treatment of severely pulmonary hypertensive …

Intervertebral disc degeneration (IVDD) is a leading cause of degenerative spinal disorders,
involving complex biological processes. This study investigates the role of the kallikrein …

Metabolic labeling with [35 S] cysteine was used to characterize early events in CaSR
biosynthesis.[35 S] CaSR is relatively stable (half-life∼ 8 h), but maturation to the final …