The immune microenvironment plays a critical role in regulating skin wound healing.
Macrophages, the main component of infiltrating inflammatory cells, play a pivotal role in …

The complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …

Heart failure (HF) management is challenging due to high clinical heterogeneity of this
disease which makes patients responding differently to evidence-based standard therapy …

The prevalence and incidence of stroke rises with life expectancy. However, except for the
use of recombinant tissue-type plasminogen activator, the translation of new therapies for …

Abstract S-Adenosyl methionine (SAMe), as a major methyl donor, exerts its influence on
central nervous system function through cellular transmethylation pathways, including the …

Epigenetic processes control the embryonic development into multicellular organisms and
determine the functional differences of genetically identical cells and individuals. They are …

Hyperglycaemia can strongly alter the epigenetic signatures in many types of human
vascular cells providing persistent perturbations of protein–protein interactions both in micro …

Many reptiles and some fish determine offspring sex by environmental cues such as
incubation temperature. The mechanism by which environmental signals are captured and …

Biological redox signaling plays an important role in many diseases. Redox signaling
involves reductive and oxidative mechanisms. Oxidative stress occurs when reductive …

The number of diabetic patients in Europe and world-wide is growing. Diabetes confers a 2-
fold higher risk for vascular disease. Lack of insulin production (Type 1 diabetes, T1D) or …