The current treatments for wound healing still exhibit drawbacks due to limited availability at
the action sites, susceptibility to degradation, and immediate drug release, all of which are …

Pharmacoresistance of cancer cells to many drugs used in chemotherapy remains a major
challenge for the treatment of cancer. Multidrug resistance transporters, especially ATP …

The taste of a herb influences its use in traditional medicine. A molecular basis for the taste-
based patterns ruling the distribution of herbal (ethno) pharmacological activities may not be …

For decades bitter taste receptors (TAS2R) were thought to be located only in the mouth and
to serve as sensors for nutrients and harmful substances. However, in recent years Tas2r …

Heart diseases and related complications constitute a leading cause of death and
socioeconomic threat worldwide. Despite intense efforts and research on the pathogenetic …

Bitter and sweet taste G protein-coupled receptors (known as T2Rs and T1Rs, respectively)
were originally identified in type II taste cells on the tongue, where they signal perception of …

Targeting inflammation and the pathways linking inflammation with cancer is an innovative
therapeutic strategy. Tastants are potential candidates for this approach, since taste …

Bitter taste receptors (TAS2Rs) Tas2r108 gene possesses a high abundance in mouse
kidney; however, the biological functions of Tas2r108 encoded receptor TAS2Rs member 4 …

Background Inflammatory microenvironment promotes odontoblastic differentiation in
human dental pulp stem cells (hDPSCs), but the regulatory mechanisms remain unclear. In …

Aim Necroptosis participates in the pathogenesis of many inflammatory diseases, including
periodontitis. Here, we aimed to investigate the role and mechanism of necroptosis inhibitors …