Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

The loss of skeletal muscle mass under a wide range of acute and chronic maladies is
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …

The ribosome is the enzymatic macromolecular machine responsible for protein synthesis.
The rates of protein synthesis are primarily dependent on translational efficiency and …

Key points For individuals showing suboptimal adaptations to resistance training,
manipulation of training volume is a potential measure to facilitate responses. This remains …

Key points Ribosome biogenesis and MYC transcription are associated with acute
resistance exercise (RE) and are distinct from endurance exercise in human skeletal muscle …

Protein synthesis and autophagy are regulated by cellular ATP content. We tested the
hypothesis that mitochondrial dysfunction, including generation of reactive oxygen species …

Skeletal muscle hypertrophy is a widely sought exercise adaptation to counteract the muscle
atrophy of aging and disease, or to improve athletic performance. While this desired muscle …

The proposed review aims to elucidate the intricate interplay between biological factors (sex
differences) and socially constructed factors (gender differences) in the context of immune …

Background A loss of muscle mass occurs as a consequence of a range of chronic and
acute diseases as well as in older age. This wasting results from an imbalance of protein …

The mammalian target of rapamycin (mTOR) complex exerts a pivotal role in protein
anabolism and cell growth. Despite its importance, few studies adequately address the …