Haemophilia

E Berntorp, K Fischer, DP Hart, ME Mancuso… - Nature reviews Disease …, 2021 - nature.com
Haemophilia A and B are rare congenital, recessive X-linked disorders caused by lack or
deficiency of clotting factor VIII (FVIII) or IX (FIX), respectively. The severity of the disease …

Contingency and determinism in evolution: Replaying life's tape

ZD Blount, RE Lenski, JB Losos - Science, 2018 - science.org
BACKGROUND Evolution is a strongly historical process, and evolutionary biology is a field
that combines history and science. How the historical nature of evolution affects the …

Modern haemophilia care

E Berntorp, AD Shapiro - The Lancet, 2012 - thelancet.com
Haemophilia care has undergone substantial improvements during the past 40–50 years.
Early clotting factor concentrates were not sufficiently refined to enable self-administered …

Past, present and future of hemophilia: a narrative review

M Franchini, PM Mannucci - Orphanet journal of rare diseases, 2012 - Springer
Over the past forty years the availability of coagulation factor replacement therapy has
greatly contributed to the improved care of people with hemophilia. Following the blood …

[HTML][HTML] An interactive mutation database for human coagulation factor IX provides novel insights into the phenotypes and genetics of hemophilia B

PM Rallapalli, G Kemball‐Cook, EG Tuddenham… - Journal of Thrombosis …, 2013 - Elsevier
Summary Background Factor IX (FIX) is important in the coagulation cascade, being
activated to FIXa on cleavage. Defects in the human F9 gene frequently lead to hemophilia …

The history of hemophilia

M Franchini, PM Mannucci - Seminars in thrombosis and …, 2014 - thieme-connect.com
Hemophilia A and B are rare inherited bleeding disorders characterized by the deficiency of
coagulation factor VIII (FVIII) or factor IX (FIX). While the history of hemophilia dates back to …

The more recent history of hemophilia treatment

M Franchini, PM Mannucci - Seminars in Thrombosis and …, 2022 - thieme-connect.com
The availability first in the 1970s of plasma-derived and then in the 1990s of recombinant
clotting factor concentrates represented a milestone in hemophilia care, enabling not only …

Surgical risk on patients with coagulopathies: guidelines on hemophiliac patients for oro-maxillofacial surgery

L Laino, M Cicciù, L Fiorillo, S Crimi, A Bianchi… - International journal of …, 2019 - mdpi.com
Background: Haemophilia is a disease of genetic origin, which causes a defect in blood
coagulation. Under normal conditions, in the case of leakage from the blood vessels, the …

The history of haemophilia–a short review

W Schramm - Thrombosis research, 2014 - Elsevier
The history of haemophilia dates back to the 2nd century AD, with the first “modern”
descriptions of the condition appearing during the 1800s. At that time, transfusion medicine …

Hemophilia A: Dental considerations and management

SP Shastry, R Kaul, K Baroudi… - Journal of International …, 2014 - journals.lww.com
Aim: To review hemophilia A with emphasis on its oral manifestations, investigations, and
dental management. Materials and Methods: Search was conducted using internet-based …