BACKGROUND Evolution is a strongly historical process, and evolutionary biology is a field that combines history and science. How the historical nature of evolution affects the …
E Berntorp, AD Shapiro - The Lancet, 2012 - thelancet.com
Haemophilia care has undergone substantial improvements during the past 40–50 years. Early clotting factor concentrates were not sufficiently refined to enable self-administered …
M Franchini, PM Mannucci - Orphanet journal of rare diseases, 2012 - Springer
Over the past forty years the availability of coagulation factor replacement therapy has greatly contributed to the improved care of people with hemophilia. Following the blood …
Summary Background Factor IX (FIX) is important in the coagulation cascade, being activated to FIXa on cleavage. Defects in the human F9 gene frequently lead to hemophilia …
M Franchini, PM Mannucci - Seminars in thrombosis and …, 2014 - thieme-connect.com
Hemophilia A and B are rare inherited bleeding disorders characterized by the deficiency of coagulation factor VIII (FVIII) or factor IX (FIX). While the history of hemophilia dates back to …
M Franchini, PM Mannucci - Seminars in Thrombosis and …, 2022 - thieme-connect.com
The availability first in the 1970s of plasma-derived and then in the 1990s of recombinant clotting factor concentrates represented a milestone in hemophilia care, enabling not only …
Background: Haemophilia is a disease of genetic origin, which causes a defect in blood coagulation. Under normal conditions, in the case of leakage from the blood vessels, the …
The history of haemophilia dates back to the 2nd century AD, with the first “modern” descriptions of the condition appearing during the 1800s. At that time, transfusion medicine …
SP Shastry, R Kaul, K Baroudi… - Journal of International …, 2014 - journals.lww.com
Aim: To review hemophilia A with emphasis on its oral manifestations, investigations, and dental management. Materials and Methods: Search was conducted using internet-based …