Caspase-2 is the most evolutionarily conserved member of the mammalian caspase family
and has been implicated in both apoptotic and non-apoptotic signaling pathways, including …

The elimination of unwanted cells by programmed cell death is a common feature of animal
development. Genetic studies in the nematode Caenorhabditis elegans, the fruit fly …

Proteolysis of cellular substrates by caspases (cysteine-dependent aspartate-specific
proteases) is one of the hallmarks of apoptotic cell death. Although the activation of …

This study re-examined the dying process in the interdigital tissue during the formation of
free digits in the developing limbs. We demonstrated that the interdigital dying process was …

Physiological cell death is a key mechanism that ensures appropriate development and
maintenance of tissues and organs in multicellular organisms. Most structures in the …

Considering the importance of programmed cell death in the formation of the skeleton during
embryonic development, the aim of the present study was to analyze whether regulated cell …

Rift Valley fever phlebovirus (RVFV) causes Rift Valley fever (RVF), an emerging zoonotic
disease that causes abortion storms and high mortality rates in young ruminants as well as …

Interdigital cell death (ICD) is the oldest and best‐studied model of programmed cell death
(PCD) in vertebrates. The classical view of ICD function is the separation of digits by …

During limb development, expression of cathepsin D and B genes prefigure the pattern of
interdigital apoptosis including the differences between the chick and the webbed digits of …

The fusion of digits or toes, syndactyly, can be part of complex syndromes, including van der
Woude syndrome. A subset of van der Woude cases is caused by dominant-negative …