The present paper considers recent progress in our understanding of the afferent/ascending
neural pathways and neural circuits of interoception. Of particular note is the extensive role …

Anxiety is experienced in response to threats that are distal or uncertain, involving changes
in one's subjective state, autonomic responses, and behavior. Defensive and physiologic …

The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

The classical theory of cortical systematic variation has been independently described in
reptiles, monotremes, marsupials and placental mammals, including primates, suggesting a …

Chronic exposure to uncontrollable stress causes loss of spines and dendrites in the
prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of …

Stress-related disorders such as depression and anxiety are characterized by enhanced
negative emotion and physiological dysfunction. Whilst elevated activity within area 25 of the …

Abstract ARNSTEN, AFT, MKP Joyce and AC Roberts. The Aversive Lens: Stress effects on
the prefrontal-cingulate cortical pathways that regulate emotion. NEUROSCI BIOBEHAV …

This paper integrates emerging evidence from two broad streams of scientific literature into
one common framework:(a) hierarchical gradients of functional connectivity that reflect the …

Emotions are temporally dynamic, but the persistence of emotions outside of their
appropriate temporal context is detrimental to health and well-being. Yet, precisely how …

We investigated afferent inputs from all areas in the frontal cortex (FC) to different
subregions in the rostral anterior cingulate cortex (rACC). Using retrograde tracing in …