DNA double-strand breaks (DSBs) are induced by a variety of genotoxic agents, including
ionizing radiation and chemotherapy drugs for treating cancers. The elimination of DSBs …

Tremendous advances in our understanding of the thrombotic microangiopathies (TMAs)
have revealed distinct disease mechanisms within this heterogeneous group of diseases. As …

Several abnormalities in complement genes reportedly contribute to atypical hemolytic
uremic syndrome (aHUS), but incomplete penetrance suggests that additional factors are …

Hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia,
thrombocytopenia, and acute renal failure. The atypical form of HUS is a disease …

Factor H related proteins comprise a group of five plasma proteins: CFHR1, CFHR2,
CFHR3, CFHR4 and CFHR5, and each member of this group binds to the central …

Complement is the major humoral component of the innate immune system. It recognizes
pathogen-and damage-associated molecular patterns, and initiates the immune response in …

Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy defined by
thrombocytopenia, nonimmune microangiopathic hemolytic anemia, and acute renal failure …

Thrombotic microangiopathy (TMA) is a pathological process involving thrombocytopenia,
microangiopathic haemolytic anaemia and microvascular occlusion. TMA is common to …

The implementation of next‐generation sequencing technologies has provided a sharp
picture of the genetic variability in the components and regulators of the alternative pathway …

Background Pregnancy is associated with various forms of thrombotic microangiopathy,
including hemolytic uremic syndrome. A previous small French study suggested that …