▪ Abstract Comparative modeling predicts the three-dimensional structure of a given protein
sequence (target) based primarily on its alignment to one or more proteins of known …

The ultimate goal of protein modeling is to predict a structure from its sequence with an
accuracy that is comparable to the best results achieved experimentally. This would allow …

We describe MUSCLE, a new computer program for creating multiple alignments of protein
sequences. Elements of the algorithm include fast distance estimation using k mer counting …

The PSIPRED protein structure prediction server allows users to submit a protein sequence,
perform a prediction of their choice and receive the results of the prediction both textually via …

The ability to separate correct models of protein structures from less correct models is of the
greatest importance for protein structure prediction methods. Several studies have examined …

Secondary structure predictions are increasingly becoming the workhorse for several
methods aiming at predicting protein structure and function. Here we use ensembles of …

Signals generated in response to extracellular stimuli at the plasma membrane are
transmitted through cytoplasmic transduction cascades to the nucleus. We report the …

Motivation: Homology or comparative modeling is currently the most accurate method to
predict the three-dimensional structure of proteins. It generally consists in four steps:(1) …

A method (three-dimensional position-specific scoring matrix, 3D-PSSM) to recognise
remote protein sequence homologues is described. The method combines the power of …

In life sciences, scientists are confronted with an exponential growth of biological data,
especially in the genomics and proteomics area. The efficient management and use of these …