Androgens and androgen receptors (AR) play a pivotal role in expression of the male
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …

Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement
on SRC function. However, a significant body of work has defined Src family kinases as key …

The androgen receptor (AR), ligand-induced transcription factor, is expressed in primary
prostate cancer and in metastases. AR regulates multiple cellular events, proliferation …

The androgen receptor (AR) signaling axis plays a critical role in the development, function
and homeostasis of the prostate. The classical action of AR is to regulate gene …

Bone cancers are characterised by the development of tumour cells in bone sites,
associated with a dysregulation of their environment. In the last two decades, numerous …

Androgen receptor (AR) signaling is a critical pathway for prostate cancer cells, and
androgen-deprivation therapy (ADT) remains the principal treatment for patients with locally …

Simple Summary Prostate cancer can develop under hormone treatment and chemotherapy
from a castration-sensitive towards a castration-resistant into a drug resistant-tumor. The …

With increases in the mortality rate and number of patients with prostate cancer (PCa), PCa,
particularly the advanced and metastatic disease, has been the focus of a number of studies …

Prostate cancer (PCa) represents a major cause of cancer mortality among men in
developed countries. Patients with recurrent disease initially respond to androgen …

Dominant mutations or DNA amplification of tyrosine kinases are rare among the oncogenic
alterations implicated in prostate cancer. We demonstrate that castration-resistant prostate …