The origin of organismal complexity is generally thought to be tightly coupled to the
evolution of new gene functions arising subsequent to gene duplication. Under the classical …

Genetic mapping provides a powerful approach to identify genes and biological processes
underlying any trait influenced by inheritance, including human diseases. We discuss the …

Fruit flies of the genus Drosophila have been an attractive and effective genetic model
organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them …

Polycomb group (PcG) proteins play important roles in maintaining the silent state of HOX
genes. Recent studies have implicated histone methylation in long-term gene silencing …

Gene regulatory networks are the most complex, extensive control systems found in nature.
The interaction between biology and evolution has been the subject of great interest in …

Human chronic myelogenous leukaemia is characterized by a reciprocal translocation
between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and …

Gene expression is central to the genotype-phenotype relationship in all organisms, and it is
an important component of the genetic basis for evolutionary change in diverse aspects of …

Hox genes encode a family of transcriptional regulators that elicit distinct developmental
programmes along the head-to-tail axis of animals. The specific regional functions of …

The worldwide importance of human hepatitis B virus infection and the toll it takes in chronic
liver disease, cirrhosis and hepatocarcinoma, make it imperative that a vaccine be …

A repetitive DNA sequence has been identified in the Drosophila melanogaster genome that
appears to be localized specifically within genes of the bithorax and Antennapedia …