Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during
embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds …

Comprising the majority of leukocytes in humans, neutrophils are the first immune cells to
respond to inflammatory or infectious etiologies and are crucial participants in the proper …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes
underlying the development and maintenance of adult tissue homeostasis, including …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

Notch signaling has been shown over the past few decades to play fundamental roles in a
plethora of developmental processes in an evolutionarily conserved fashion. Notch …

We aimed to identify genetic variants associated with cortical bone thickness (CBT) and
bone mineral density (BMD) by performing two separate genome-wide association study …

Wnt signaling is involved in self-renewal and maintenance of hematopoietic stem cells
(HSCs); however, the particular role of noncanonical Wnt signaling in regulating HSCs in …

Hypercholesterolemia, the driving force of atherosclerosis, accelerates the expansion and
mobilization of hematopoietic stem and progenitor cells (HSPCs). The molecular …