Covalent inhibitors and other types of covalent modalities have seen a revival in the past two
decades, with a variety of new targeted covalent drugs having been approved in recent …

Selective introduction of a double bond motif into a multifunctional organic compound is
always a big challenge. The Horner–Wadsworth–Emmons reaction is one of the most …

Human ornithine aminotransferase (h OAT), a pyridoxal 5′-phosphate (PLP)-dependent
enzyme, has been shown to play an essential role in the metabolic reprogramming and …

Inhibition of human ornithine aminotransferase interferes with glutamine and proline
metabolism in hepatocellular carcinoma, depriving tumors of essential nutrients. A proposed …

The gyrate atrophy of the choroid and retina (GACR) is a rare genetic disease for which no
definitive cure is available. GACR is due to the deficit of ornithine aminotransferase (hOAT) …

Ornithine aminotransferase (OAT) is overexpressed in hepatocellular carcinoma (HCC), and
we previously showed that inactivation of OAT inhibits the growth of HCC. Recently, we …

Objective The sensitivity and specificity of current biomarkers for gastric cancer were
insufficient. The aim of the present study was to screen novel biomarkers and determine the …

We applied molecular docking simulations and DFT to examine the binding interactions of 4-
difluoromethyl pyrazole derivatives (3a-3h). We assessed the potential binding mechanisms …

Natural products and natural product analogs play a key role in drug discovery. Natural
products are a broad range of small molecules, from basic building blocks like amino acids …