Autophagy plays a crucial role in maintaining cellular homeostasis, and is closely related to
the occurrence of variety of human diseases. It is known that autophagy occurs in response …

All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

The mechanistic target of rapamycin (mTOR) has gathered significant attention as a
ubiquitously expressed multimeric kinase with key implications for cell growth, proliferation …

Macroautophagy is a lysosomal degradative pathway or recycling process that maintains
cellular homeostasis. This autophagy involves a series of sequential processing events …

Autophagy is a process of self-degradation that enables the cell to survive when faced with
starvation or stressful conditions. The mechanistic target of rapamycin (mTOR), also known …

Association of diabetes with an elevated risk of cardiac failure has been clinically evident.
Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction …

Necrosis that appears at the ischemic distal end of random-pattern skin flaps increases the
pain and economic burden of patients. Necroptosis is thought to contribute to flap necrosis …

Metastasis and relapse account for the great majority of cancer-related deaths. Most
metastatic lesions are micro metastases that have the capacity to remain in a non-dividing …

Autophagy is a cellular stress response mechanism activation of which leads to degradation
of cellular components, including proteins as well as damaged organelles in lysosomes …

Cells of an organism face with various types of insults during their lifetime. Exposure to
toxins, metabolic problems, ischaemia/reperfusion, physical trauma, genetic diseases …