Acquired von Willebrand syndrome associated with left ventricular assist device
A Nascimbene, S Neelamegham… - Blood, The Journal …, 2016 - ashpublications.org
Left ventricular assist devices (LVAD) provide cardiac support for patients with end-stage
heart disease as either bridge or destination therapy, and have significantly improved the …
heart disease as either bridge or destination therapy, and have significantly improved the …
Flow-induced elongation of von Willebrand factor precedes tension-dependent activation
Von Willebrand factor, an ultralarge concatemeric blood protein, must bind to platelet GPIbα
during bleeding to mediate hemostasis, but not in the normal circulation to avoid thrombosis …
during bleeding to mediate hemostasis, but not in the normal circulation to avoid thrombosis …
Type 2A and 2M von Willebrand disease: differences in phenotypic parameters according to the affected domain by disease-causing variants and assessment of …
AI Woods, J Paiva, DM Primrose… - … in Thrombosis and …, 2021 - thieme-connect.com
Type 2A and 2M von Willebrand disease (VWD) broadly show similar phenotypic
parameters, but involve different pathophysiological mechanisms. This report presents the …
parameters, but involve different pathophysiological mechanisms. This report presents the …
Free hemoglobin increases von Willebrand factor–mediated platelet adhesion in vitro: implications for circulatory devices
Q Da, M Teruya, P Guchhait, J Teruya… - Blood, The Journal …, 2015 - ashpublications.org
Intravascular hemolysis occurs in patients on extracorporeal membrane oxygenation. High
levels of free acellular adult hemoglobin (free HbA) are associated with clotting in this …
levels of free acellular adult hemoglobin (free HbA) are associated with clotting in this …
The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Ibα
Binding of platelet glycoprotein Ibα (GPIbα) to von Willebrand factor (VWF) initiates platelet
adhesion to disrupted vascular surface under arterial blood flow. Flow exerts forces on the …
adhesion to disrupted vascular surface under arterial blood flow. Flow exerts forces on the …
Von Willebrand factor-A1 domain binds platelet glycoprotein Ibα in multiple states with distinctive force-dependent dissociation kinetics
Circulating von Willebrand factor (VWF) adopts a closed conformation that shields the
platelet glycoprotein Ibα (GPIbα) binding site in the VWF-A1 domain. Immobilized at sites of …
platelet glycoprotein Ibα (GPIbα) binding site in the VWF-A1 domain. Immobilized at sites of …
[图书][B] Platelets in thrombotic and non-thrombotic disorders: pathophysiology, pharmacology and therapeutics: an update
This book reviews current science and applications in fields including thrombosis and
hemostasis, signal transduction, and non-thrombotic conditions such as inflammation …
hemostasis, signal transduction, and non-thrombotic conditions such as inflammation …
A novel interaction between extracellular vimentin and fibrinogen in fibrin formation
M Martinez-Vargas, A Cebula, LS Brubaker… - Thrombosis research, 2023 - Elsevier
Introduction Thrombosis is frequently manifested in critically ill patients with systemic
inflammation, including sepsis and COVID-19. The coagulopathy in systemic inflammation is …
inflammation, including sepsis and COVID-19. The coagulopathy in systemic inflammation is …
von Willebrand factor, free hemoglobin and thrombosis in ECMO
C Valladolid, A Yee, MA Cruz - Frontiers in Medicine, 2018 - frontiersin.org
Though extracorporeal membrane oxygenation (ECMO) provides life-saving support, this
intervention exposes patients to certain risks. Circulating free hemoglobin (fHb) resulting …
intervention exposes patients to certain risks. Circulating free hemoglobin (fHb) resulting …
Platelet adhesion involves a novel interaction between vimentin and von Willebrand factor under high shear stress
Q Da, M Behymer, JI Correa… - Blood, The Journal of …, 2014 - ashpublications.org
The interaction between platelet receptor glycoprotein Ibα and the A1 domain of von
Willebrand factor (VWF) mediates tethering/translocation of platelets to sites of vascular …
Willebrand factor (VWF) mediates tethering/translocation of platelets to sites of vascular …