Targeting growth factor and cytokine pathways to treat idiopathic pulmonary fibrosis

H Ma, S Liu, S Li, Y Xia - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease of unknown origin
that usually results in death from secondary respiratory failure within 2–5 years of diagnosis …

Transcriptomic evidence of immune activation in macroscopically normal-appearing and scarred lung tissues in idiopathic pulmonary fibrosis

IG Luzina, MV Salcedo, ML Rojas-Peña, AE Wyman… - Cellular …, 2018 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease manifested by overtly scarred
peripheral and basilar regions and more normal-appearing central lung areas. Lung tissues …

Facts and promises on lung biomarkers in interstitial lung diseases

I Campo, M Zorzetto, F Bonella - Expert review of respiratory …, 2015 - Taylor & Francis
Interstitial lung diseases (ILDs) are a heterogeneous group of> 100 pulmonary disorders.
ILDs are characterized by an irreversible architectural distortion and impaired gas …

[HTML][HTML] IL-4Rα expression by airway epithelium and smooth muscle accounts for nearly all airway hyperresponsiveness in murine allergic airway disease

CG McKnight, C Potter, FD Finkelman - Mucosal immunology, 2020 - Elsevier
Airway hyperresponsiveness (AHR) often defines asthma. Murine allergic airway disease
(AAD), like human eosinophilic asthma, is characterized by AHR, eosinophilia, goblet cell …

Chemokine release from human rhinovirus–infected airway epithelial cells promotes fibroblast migration

C Shelfoon, S Shariff, SL Traves, C Kooi… - Journal of Allergy and …, 2016 - Elsevier
Background Thickening of the lamina reticularis, a feature of remodeling in the asthmatic
airways, is now known to be present in young children who wheeze. Human rhinovirus …

[HTML][HTML] Homocysteine mediates transcriptional changes of the inflammatory pathway signature genes in human retinal pigment epithelial cells

M Singh, SC Tyagi - International Journal of Ophthalmology, 2017 - ncbi.nlm.nih.gov
AIM To test whether homocysteine (Hcy) can influence the transcriptional profile, we
hypothesized that Hcy can lead to the induction of proinflammatory molecules in the retinal …

CXCR3A promotes the secretion of the antifibrotic decoy receptor sIL-13Rα2 by pulmonary fibroblasts

JC Worrell, SM Walsh, A Fabre… - … of Physiology-Cell …, 2020 - journals.physiology.org
CXC chemokine receptor 3 (CXCR3) A and its IFN-inducible ligands CXCL9 and CXCL10
regulate vascular remodeling and fibroblast motility. IL-13 is a profibrotic cytokine implicated …

A dataset of 26 candidate gene and pro-inflammatory cytokine variants for association studies in idiopathic pulmonary fibrosis: frequency distribution in normal Czech …

A Kishore, V Žižková, L Kocourková… - Frontiers in …, 2015 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive fibrosing
interstitial pneumonia with poor diagnosis and a median survival of 2–3 years from initial …

[HTML][HTML] Prognostic impact of a novel gene expression profile classifier for the discrimination between metastatic and non-metastatic primary colorectal cancer tumors

ML Gutiérrez, LA Corchete, ME Sarasquete… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Despite significant advances have been achieved in the genetic characterization of sporadic
colorectal cancer (sCRC), the precise genetic events leading to the development of distant …

[PDF][PDF] Effect of IL-13Rα2 on TGF-β expression and collagen synthesizing induced by IL-13 in human lung fibroblasts HFL-1

CQX Liu, P Huang, JP Xiong, LX Xiong - Int J Clin Exp Pathol, 2017 - e-century.us
IL-13 is a pro-fibrotic cytokine that can bind to two receptors, IL-13Rα1 and IL-13Rα2. IL-
13Rα2 used to be regarded as a decoy receptor. However, recent studies indicated that it …