RNA processing includes post-transcriptional mechanisms controlling RNA quality and
quantity to ensure cellular homeostasis. Noncoding (nc) RNAs that are regulated by these …

Topologically associating domain (TAD) boundaries are the flanking edges of TADs, also
known as insulated neighborhoods, within the 3D structure of genomes. A prominent feature …

G0-G1 phase alternative end joining (A-EJ) is a recently defined mutagenic pathway
characterized by resected deletion and translocation joints that are predominantly direct and …

In developing B cells, V (D) J recombination assembles exons encoding IgH and Igκ
variable regions from hundreds of gene segments clustered across Igh and Igk loci. V, D and …

The dynamic folding of genomes regulates numerous biological processes, including
antigen receptor (AgR) gene assembly. We show that, unlike other AgR loci, homotypic …

The expressed Ab repertoire is a critical determinant of immune-related phenotypes. Ab-
encoding transcripts are distinct from other expressed genes because they are transcribed …

The generation of highly diverse antigen receptors in T and B lymphocytes relies on V (D) J
recombination. The enhancer Eα has been implicated in regulating the accessibility of Vα …

The vast diversity of mammalian adaptive antigen receptors allows for robust and efficient
immune responses against a wide number of pathogens. The antigen receptor repertoire is …

While extended loop extrusion across the entire Igh locus controls VH‐DJH recombination,
local regulatory sequences, such as the PAIR elements, may also activate VH gene …

Effective Ab-mediated responses depend on a highly diverse Ab repertoire with the ability to
bind a wide range of epitopes in disease-causing agents. The generation of this repertoire …