Cellular barcodes are distinct DNA sequences that enable one to track specific cells across
time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes …

With respect to their ontogeny, emerging data support a lymphoid origin of plasmacytoid
dendritic cells (pDCs), which seem to share a developmental trajectory with B cells. By …

High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs),
including a population of transitional DCs (tDCs) in mice and humans. However, the origin …

The human blood system is maintained through the differentiation and massive amplification
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …

In response to infections and stress, hematopoiesis rapidly enhances blood and immune
cell production. The stage within the hematopoietic hierarchy that accounts for this …

Plasmacytoid dendritic cells (pDCs) represent a unique cell type within the innate immune
system. Their defining property is the recognition of pathogen-derived nucleic acids through …

Plasmacytoid dendritic cells (pDCs) are the main source of type I interferon (IFN-I) during
viral infections. Their other functions are debated, due to a lack of tools to identify and target …

Dendritic cells (DCs) are sentinel immune cells that form a critical bridge linking the innate
and adaptive immune systems. Extensive research addressing the cellular origin and …

Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …

Since their discovery, the identity of plasmacytoid dendritic cells (pDCs) has been at the
center of a continuous dispute in the field, and their classification as dendritic cells (DCs) …