Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and
represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and …

Cranial placodes (which include the adenohypophyseal, olfactory, lens, otic, lateral line,
profundal/trigeminal, and epibranchial placodes) give rise to many sense organs and …

Inner-ear hair cell differentiation requires Atoh1 function, while Eya1, Six1, and Sox2 are
coexpressed in sensory progenitors and mutations in these genes cause sensorineural …

Multiple genetic mutations within melanoma not only cause lesion-specific responses to
targeted therapy but also alter the molecular route of resistance to that therapy. Inactivation …

Homeobox genes encode transcription factors that are essential for normal development
and are often dysregulated in cancers. The molecular mechanisms that cause their …

Ewing sarcoma (ES), which is characterized by the presence of oncogenic fusion proteins
such as EWS/FLI1, is an aggressive pediatric malignancy with a high rate of early …

Rhabdomyosarcoma (RMS) is a mesenchymal malignancy composed of neoplastic primitive
precursor cells that exhibit histological features of myogenic differentiation. Despite intensive …

Six1 is a developmentally regulated homeoprotein with limited expression in most normal
adult tissues and frequent misexpression in a variety of malignancies. Here we demonstrate …

In breast cancer, an uncontrolled cell proliferation leads to tumor formation and development
of a multifactorial disease. Metastasis is a complex process that involves tumor spread to …

Rhabdomyosarcoma (RMS) is an aggressive childhood mesenchymal tumor with two major
molecular and histopathologic subtypes: fusion-positive (FP) RMS, characterized by the …