Allogenous selection of mutational collateral resistance: old drugs select for new resistance within antibiotic families
Allogeneous selection occurs when an antibiotic selects for resistance to more advanced
members of the same family. The mechanisms of allogenous selection are (a) collateral …
members of the same family. The mechanisms of allogenous selection are (a) collateral …
Epistasis decreases with increasing antibiotic pressure but not temperature
Predicting mutational effects is essential for the control of antibiotic resistance (ABR).
Predictions are difficult when there are strong genotype-by-environment (G× E), gene-by …
Predictions are difficult when there are strong genotype-by-environment (G× E), gene-by …
Evolution of antibiotic resistance impacts optimal temperature and growth rate in Escherichia coli and Staphylococcus epidermidis
P Mira, N Lozano‐Huntelman, A Johnson… - Journal of Applied …, 2022 - academic.oup.com
Aims Bacterial response to temperature changes can influence their pathogenicity to plants
and humans. Changes in temperature can affect cellular and physiological responses in …
and humans. Changes in temperature can affect cellular and physiological responses in …
Evolutionary druggability for low-dimensional fitness landscapes toward new metrics for antimicrobial applications
RF Guerrero, T Dorji, MH Ra'Mal, MD Shoulders… - Elife, 2024 - elifesciences.org
The term 'druggability'describes the molecular properties of drugs or targets in
pharmacological interventions and is commonly used in work involving drug development …
pharmacological interventions and is commonly used in work involving drug development …
Understanding the effects of sub-inhibitory antibiotic concentrations on the development of β-lactamase resistance based on quantile regression analysis
P Mira, C Guzman-Cole, JC Meza - Journal of Applied …, 2024 - academic.oup.com
Aims Quantile regression is an alternate type of regression analysis that has been shown to
have numerous advantages over standard linear regression. Unlike linear regression, which …
have numerous advantages over standard linear regression. Unlike linear regression, which …
[HTML][HTML] Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications
RF Guerrero, T Dorji, MH Ra'Mal, MD Shoulders… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The term “druggability” describes the molecular properties of drugs or targets in
pharmacological interventions and is commonly used in work involving drug development …
pharmacological interventions and is commonly used in work involving drug development …
Epistasis decreases with increasing antibiotic pressure but not temperature
Predicting mutational effects is important for the control of antibiotic resistance (ABR).
Predictions are difficult when there are strong genotype-by-environment (G× E), gene-by …
Predictions are difficult when there are strong genotype-by-environment (G× E), gene-by …
[PDF][PDF] Epistasis decreases with increasing antibiotic pressure but not temperature
S Hawking - Fitness landscapes for predicting evolution between …, 2023 - run.unl.pt
It has been debated for decades whether gene-by-gene interactions (G× G or epistasis)
influence evolutionary processes (reviewed in [1, 2]). Compelling evidence for the …
influence evolutionary processes (reviewed in [1, 2]). Compelling evidence for the …
[PDF][PDF] Rafael F. Guerrero, Tandin Dorji 2, Ra'Mal M. Harris 3, Matthew D. Shoulders 3, C. 5
B Ogbunugafor - biorxiv.org
The term “druggability” describes the molecular properties of drugs or targets in 13
pharmacological interventions and is commonly used in work involving drug development …
pharmacological interventions and is commonly used in work involving drug development …