Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

Abstract TAR DNA-binding protein 43 (TDP-43) aggregation is the most common
pathological hallmark in frontotemporal dementia (FTD) and characterizes nearly all patients …

Depending on cell type, environmental inputs, and disease, the cells in the human body can
have widely different sizes. In recent years, it has become clear that cell size is a major …

Increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor
in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still know very little about the …

TDP-43 aggregates in neurons and glia are the defining pathological hallmark of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), raising the …

Recent evidence has supported the hypothesis that amyotrophic lateral sclerosis (ALS) is a
multi-step disease, as the onset of symptoms occurs after sequential exposure to a defined …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with an average age-of-
onset of∼ 60 years and is usually fatal within 2–5 years of diagnosis. Mouse models based …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease and is
clinically characterised by the death of corticospinal motor neurons (CSMNs), spinal and …

Spinal motor neurons have been implicated in the loss of motor function that occurs with
advancing age. However, the cellular and molecular mechanisms that impair the function of …