Japanese Encephalitis Virus: an update on the potential antivirals and vaccines

KS Srivastava, V Jeswani, N Pal, B Bohra… - Vaccines, 2023 - mdpi.com
Japanese encephalitis virus (JEV) is the causal agent behind Japanese encephalitis (JE), a
potentially severe brain infection that spreads through mosquito bites. JE is predominant …

Tropane alkaloids (hyoscyamine, scopolamine and atropine) from genus Datura: Extractions, contents, syntheses and effects

Z Shi, W Zou, Z Zhu, Z Xiong, S Li, P Dong… - Industrial Crops and …, 2022 - Elsevier
Belonging to family Solanaceae, genus Datura is widely distributed all over the world and
famous for its narcosis and acesodyne in ancient China. And Datura is also annoying due to …

Molecular mechanism and role of Japanese encephalitis virus infection in central nervous system-mediated diseases

P Yadav, P Chakraborty, NK Jha, S Dewanjee, AK Jha… - Viruses, 2022 - mdpi.com
The Japanese encephalitis virus (JEV) is the most common cause of neurodegenerative
disease in Southeast Asia and the Western Pacific region; approximately 1.15 billion people …

Antiviral drug research for Japanese encephalitis: an updated review

S Joe, AAA Salam, U Neogi, NB N, PP Mudgal - Pharmacological Reports, 2022 - Springer
Japanese encephalitis (JE) caused by the Japanese encephalitis virus (JEV) is one of Asia's
most common viral encephalitis. JEV is a flavivirus, common in rural and sub-urban regions …

NMDA receptor blockade attenuates Japanese encephalitis virus infection-induced microglia activation

CY Chang, CC Wu, CY Tzeng, JR Li, YF Chen… - Journal of …, 2024 - Springer
Neurodegeneration and neuroinflammation are key components in the pathogenesis of
Japanese Encephalitis caused by Japanese Encephalitis Virus (JEV) infection. The N …

Human microglial models to study host–virus interactions

RE McMillan, E Wang, AF Carlin, NG Coufal - Experimental neurology, 2023 - Elsevier
Microglia, the resident macrophage of the central nervous system, are increasingly
recognized as contributing to diverse aspects of human development, health, and disease …

Recent advances in antivirals for Japanese encephalitis virus

Y Zhu, S Chen, Q Lurong, Z Qi - Viruses, 2023 - mdpi.com
Culex mosquitoes are the primary vectors of the Japanese encephalitis virus (JEV). Since its
discovery in 1935, Japanese encephalitis (JE), caused by JEV, has posed a significant …

Recent advances to overcome the burden of Japanese encephalitis: A zoonotic infection with problematic early detection

KK Pinapati, R Tandon, P Tripathi… - Reviews in Medical …, 2023 - Wiley Online Library
Japanese encephalitis (JE) is a vector‐borne neurotropic disease caused by Japanese
encephalitis virus (JEV) associated with high mortality rate distributed from Eastern and …

Anti-Cryptosporidial Drug-Discovery Challenges and Existing Therapeutic Avenues: A “One-Health” Concern

M Ali, C Xu, S Nawaz, AE Ahmed, Q Hina, K Li - Life, 2024 - mdpi.com
Cryptosporidiosis is the leading cause of life-threatening diarrheal infection, especially in
infants. Oocysts contaminate the environment, and also, being a zoonotic disease …

Antiviral and anti‐inflammatory activity of natural compounds against Japanese encephalitis virus via inhibition of NS5 protein and regulation of key immune and …

VK Maurya, S Kumar, S Ansari… - Journal of Medical …, 2023 - Wiley Online Library
Japanese encephalitis virus (JEV) is the foremost cause of viral encephalitis in Southeast
Asia and Australia leading to approximately 68 000 clinical cases and about 13 600− 20 400 …