The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …

Especially in tropical and developing countries, the clinically relevant protozoa
Trypanosoma cruzi (Chagas disease), Trypanosoma brucei (sleeping sickness) and …

Leishmaniases still represent a global scourge and new therapeutic tools are necessary to
replace the current expensive, difficult to administer treatments that induce numerous …

Highlights•Anti-leishmanial drugs available today pose severe side effects and are not
affordable.•Identifying suitable drug target is essential for effective drug development.•Target …

Carajurin is the main constituent of Arrabidaea chica species with reported anti-Leishmania
activity. However, its mechanism of action has not been described. This study investigated …

The control of the protozoan parasite Leishmania relies on few drugs with unknown cellular
targets and unclear mode of action. Several antileishmanials, however, were shown to …

American cutaneous leishmaniasis is a zoonotic disease caused by protozoans of the genus
Leishmania. The treatment of cutaneous leishmaniasis is unsatisfactory, thus, much …

A decade of genome sequencing has transformed our understanding of how trypanosomatid
parasites have evolved and provided fresh impetus to explaining the origins of parasitism in …

Protozoan diseases such as malaria, leishmaniasis, Chagas disease, and sleeping sickness
still levy a heavy toll on human lives. Deplorably, only few classes of anti-protozoan drugs …

Background Chagas disease is a health threat for many people, mostly those living in Latin
America. One of the most important problems in treatment is the limitation of existing drugs …