The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular
volume homeostasis and blood pressure through complex mechanisms. Apart from the well …

Diabetes mellitus is known to trigger retinopathy, neuropathy and nephropathy. Diabetic
nephropathy, a long-term major microvascular complication of uncontrolled hyperglycemia …

Vitamin D regulates the renin-angiotensin system (RAS) in experimental animals, but
corresponding human data are limited. We examined the relation between plasma 25 …

Angiotensin II content in the kidney is much higher than in the plasma, and it increases more
in kidney diseases through an uncertain mechanism. Because the kidney abundantly …

Patients with diabetic nephropathy have a higher risk of mortality, mostly from cardiovascular
complications. Standard biomarkers including serum creatinine, estimated glomerular …

Loss of Klotho and activation of the renin-angiotensin system (RAS) are common
pathological findings in chronic kidney diseases. However, whether these two events are …

Activation of the intrarenal renin-angiotensin system (RAS) can elicit hypertension
independently from the systemic RAS. However, the precise mechanisms by which …

Patients with chronic kidney disease (CKD) are prone to developing cardiac hypertrophy
and fibrosis, which is associated with increased fibroblast growth factor 23 (FGF23) serum …

In chronic kidney disease (CKD), enhanced intrarenal angiotensin II (AngII) is involved in
deterioration of renal function, but it is difficult to measure it. For assessment of the potential …

Results After multivariable adjustment, the highest tertile of three urinary biomarkers
remained associated with AKI progression compared with the lowest tertile: uAGT (odds …