Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease of the
human motor system. Aetiological mechanisms implicated in the development of ALS have …

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease, which is characterized by
the degeneration of motor neurons in the motor cortex and the spinal cord and subsequently …

Objective To determine the long‐term survival in amyotrophic lateral sclerosis (ALS) and
identify predictors of prolonged survival in a population‐based cohort of newly diagnosed …

Objective: To test the safety of spinal cord transplantation of human stem cells in patients
with amyotrophic lateral sclerosis (ALS) with escalating doses and expansion of the trial to …

Importance Various factors have been proposed as possible candidates associated with the
prognosis of amyotrophic lateral sclerosis (ALS); however, there is still no consensus on …

Background Selection of appropriate trial endpoints and outcome measures is particularly
important in rare disease and rapidly progressing disease such as amyotrophic lateral …

Background and purpose To assess the efficacy and safety of olesoxime, a molecule with
neuroprotective properties, in patients with amyotrophic lateral sclerosis (ALS) treated with …

Objectives The use of clinical staging in the fatal neurodegenerative disease amyotrophic
lateral sclerosis would have value in optimising future therapeutic trials. We aimed to use …

Importance Understanding the natural history of familial amyotrophic lateral sclerosis (ALS)
caused by SOD1 mutations (ALSSOD1) will provide key information for optimising clinical …

Normal sleep-related rapid eye movement sleep atonia, reduced lung volumes, reduced
chemosensitivity, and impaired airway dilator activity become significant vulnerabilities in …