Traditional organic antimicrobials mainly act on specific biochemical processes such as
replication, transcription and translation. However, the emergence and wide spread of …

The rich diversity of coordination chemistry provides exciting prospects for the design of
novel therapeutic agents with unique mechanisms of action. Central to such discovery is the …

Metallodrugs offer potential for unique mechanisms of drug action based on the choice of
the metal, its oxidation state, the types and number of coordinated ligands and the …

Cyclams are 14-membered tetraamine macrocycles which bind strongly to a wide range of
metal ions. Medical interest has centred on clinical trials of a bicyclam for the treatment of …

Unique properties of metal complexes, such as structural diversity, adjustable ligand
exchange kinetics, fine-tuned redox activities, and distinct spectroscopic signatures, make …

AMD3100 is a symmetric bicyclam, prototype non-peptide antagonist of the CXCR4
chemokine receptor. Mutational substitutions at 16 positions located in TM-III,-IV,-V,-VI, and …

Molecular recognition of DNA, RNA, and related biomolecules is responsible for a wide
range of biochemical processes such as complementary base pairings in genetic …

Historically, Lewis acidic metal coordination complexes have played a pivotal and defining
role in the broad field of molecular recognition and more specifically in the sensing and …

The affinity of AMD3100, a symmetrical nonpeptide antagonist composed of two 1, 4, 8, 11-
tetraazacyclotetradecane (cyclam) rings connected through a 1, 4-dimethylene (phenylene) …

The absolute necessity to fight some class of tumour is perceived as serious health
concerns, and the discovery and development of effective anticancer agents are urgently …