Although the term “asthma” has been applied to all patients with airway lability and variable
chest symptoms for centuries, phenotypes of asthma with distinct clinical and molecular …

Allergen immunotherapy (AIT) has been in use for the treatment of allergic disease for more
than 100 years. Asthma treatment relies mainly on corticosteroids and other controllers …

A paradigm shift brought by the recognition that childhood asthma is an aggregated
diagnosis that comprises several different endotypes underpinned by different …

Rationale: Longitudinal modeling of current wheezing identified similar phenotypes, but their
characteristics often differ between studies. Objectives: We propose that a more …

Patients who are prone to exacerbations of asthma experience significant costs in terms of
missed work and school, acute care visits, and hospitalizations. Exacerbations are largely …

Acute attacks of wheeze or asthma are among the most common reasons for paediatric
hospital attendance, and the incidence of severe attacks in the UK is among the highest in …

Asthma is a major driver of health care costs across ages. Despite widely disseminated
asthma-treatment guidelines and a growing variety of effective therapeutic options, most …

Objective To summarize the recent evidence in the treatment of viral-induced wheezing in
the infant and preschool aged child. Data Sources Published literature obtained through …

Background Clustering techniques can define the heterogeneity of asthma and wheezing.
Defining early‐life wheezing clusters and associated asthma risk could potentially inform …

Background Although clinical features of type 2 inflammation have been associated with
poorer longitudinal outcomes in preschool children with recurrent wheezing, it remains …