Human antimicrobial peptides as therapeutics for viral infections

A Ahmed, G Siman-Tov, G Hall, N Bhalla, A Narayanan - Viruses, 2019 - mdpi.com
Successful in vivo infection following pathogen entry requires the evasion and subversion of
multiple immunological barriers. Antimicrobial peptides (AMPs) are one of the first immune …

Immunomodulatory role of the antimicrobial LL-37 peptide in autoimmune diseases and viral infections

B Pahar, S Madonna, A Das, C Albanesi, G Girolomoni - Vaccines, 2020 - mdpi.com
Antimicrobial peptides (AMPs) are produced by neutrophils, monocytes, and macrophages,
as well as epithelial cells, and are an essential component of innate immunity system …

Effect of high doses of vitamin D supplementation on dengue virus replication, Toll-like receptor expression, and cytokine profiles on dendritic cells

J Martínez-Moreno, JC Hernandez… - Molecular and Cellular …, 2020 - Springer
Dengue, caused by dengue virus (DENV) infection, is a public health problem worldwide.
Although DENV pathogenesis has not yet been fully elucidated, the inflammatory response …

Antiviral and immunomodulatory properties of antimicrobial peptides produced by human keratinocytes

C Chessa, C Bodet, C Jousselin, M Wehbe… - Frontiers in …, 2020 - frontiersin.org
Keratinocytes, the main cells of the epidermis, are the first site of replication as well as the
first line of defense against many viruses such as arboviruses, enteroviruses, herpes …

Antiviral activities of human host defense peptides

DC Brice, G Diamond - Current medicinal chemistry, 2020 - ingentaconnect.com
Peptides with broad-spectrum antimicrobial activity are found widely expressed throughout
nature. As they participate in a number of different aspects of innate immunity in mammals …

Vitamin D-induced LL-37 modulates innate immune responses of human primary macrophages during DENV-2 infection

JA Castillo, DM Giraldo, JM Smit… - Pathogens and …, 2022 - academic.oup.com
Epidemics of dengue, an acute and potentially severe disease caused by mosquito-borne
dengue virus (DENV), pose a major challenge to clinicians and health care services across …

pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread

TH Benedyk, J Muenzner, V Connor, Y Han… - PLoS …, 2021 - journals.plos.org
The herpes simplex virus (HSV)-1 protein pUL21 is essential for efficient virus replication
and dissemination. While pUL21 has been shown to promote multiple steps of virus …

LL-37-Induced Autophagy Contributed to the Elimination of Live Porphyromonas gingivalis Internalized in Keratinocytes

X Yang, L Niu, Y Pan, X Feng, J Liu, Y Guo… - Frontiers in cellular …, 2020 - frontiersin.org
Porphyromonas gingivalis (P. gingivalis), one of the most important pathogens of
periodontitis, is closely associated with the aggravation and recurrence of periodontitis and …

Cathelicidins target hsp60 to restrict cvb3 transmission via disrupting the exosome and reducing cardiomyocyte apoptosis

Y Yang, C Huang, L Hui, Y Song, Y Fu, M Li… - Journal of …, 2023 - Am Soc Microbiol
Cathelicidin antimicrobial peptides (mouse, CRAMP; human, LL-37) have broad-spectrum
antiviral activities against enveloped viruses, but their mechanisms of action against …

The restrictome of flaviviruses

L Berthoux - Virologica Sinica, 2020 - Springer
Flaviviruses are a genus of mostly arthropod-borne RNA viruses that cause a range of
pathologies in humans. Basic knowledge on flaviviruses is rapidly expanding, partly due to …