Abnormal γ band activity is observed in patients with schizophrenia and disease models in animals, and is suggested to underlie the psychosis and cognitive/perceptual deficits …
I Brys, SA Barrientos, JE Ward, J Wallander… - Communications …, 2023 - nature.com
The profound changes in perception and cognition induced by psychedelic drugs are thought to act on several levels, including increased glutamatergic activity, altered functional …
D Rivolta, T Heidegger, B Scheller, A Sauer… - Schizophrenia …, 2015 - academic.oup.com
Hypofunctioning of the N-methyl-D-aspartate receptor (NMDA-R) has been prominently implicated in the pathophysiology of schizophrenia (ScZ). The current study tested the …
J Fischell, AM Van Dyke, MD Kvarta… - …, 2015 - nature.com
Selective serotonin reuptake inhibitors (SSRIs) are the primary pharmacological treatment for depression, but SSRIs are effective in only half of the patients and typically take several …
New antidepressant pharmacotherapies that provide rapid relief of depressive symptoms are needed. The NMDA receptor antagonist ketamine exerts rapid antidepressant actions in …
A Ahnaou, H Huysmans, R Biermans… - Translational …, 2017 - nature.com
Recently, the N-methyl-d-aspartate-receptor (NMDAR) antagonist ketamine has emerged as a fast-onset mechanism to achieve antidepressant activity, whereas its psychomimetic …
MJ Hunt, S Kasicki - Journal of Psychopharmacology, 2013 - journals.sagepub.com
Distinct frequency bands can be differentiated from neuronal ensemble recordings, such as local field potentials or electrocorticogram recordings. Recent years have witnessed a rapid …
Neuroanatomical, electrophysiological and behavioural abnormalities following timed prenatal methylazoxymethanol acetate (MAM) treatment in rats model changes observed in …
R McMillan, SD Muthukumaraswamy - Reviews in the Neurosciences, 2020 - degruyter.com
The drug ketamine has been extensively studied due to its use in anaesthesia, as a model of psychosis and, most recently, its antidepressant properties. Understanding the physiology of …