Neuronal dynamics and neuropsychiatric disorders: toward a translational paradigm for dysfunctional large-scale networks

PJ Uhlhaas, W Singer - Neuron, 2012 - cell.com
In recent years, numerous studies have tested the relevance of neural oscillations in
neuropsychiatric conditions, highlighting the potential role of changes in temporal …

Gamma band oscillations: a key to understanding schizophrenia symptoms and neural circuit abnormalities

JM McNally, RW McCarley - Current opinion in psychiatry, 2016 - journals.lww.com
Abnormal γ band activity is observed in patients with schizophrenia and disease models in
animals, and is suggested to underlie the psychosis and cognitive/perceptual deficits …

5-HT2AR and NMDAR psychedelics induce similar hyper-synchronous states in the rat cognitive-limbic cortex-basal ganglia system

I Brys, SA Barrientos, JE Ward, J Wallander… - Communications …, 2023 - nature.com
The profound changes in perception and cognition induced by psychedelic drugs are
thought to act on several levels, including increased glutamatergic activity, altered functional …

Ketamine dysregulates the amplitude and connectivity of high-frequency oscillations in cortical–subcortical networks in humans: evidence from resting-state …

D Rivolta, T Heidegger, B Scheller, A Sauer… - Schizophrenia …, 2015 - academic.oup.com
Hypofunctioning of the N-methyl-D-aspartate receptor (NMDA-R) has been prominently
implicated in the pathophysiology of schizophrenia (ScZ). The current study tested the …

Rapid antidepressant action and restoration of excitatory synaptic strength after chronic stress by negative modulators of alpha5-containing GABAA receptors

J Fischell, AM Van Dyke, MD Kvarta… - …, 2015 - nature.com
Selective serotonin reuptake inhibitors (SSRIs) are the primary pharmacological treatment
for depression, but SSRIs are effective in only half of the patients and typically take several …

A negative allosteric modulator for α5 subunit-containing GABA receptors exerts a rapid and persistent antidepressant-like action without the side effects of the NMDA …

P Zanos, ME Nelson, JN Highland, SR Krimmel… - eneuro, 2017 - eneuro.org
New antidepressant pharmacotherapies that provide rapid relief of depressive symptoms
are needed. The NMDA receptor antagonist ketamine exerts rapid antidepressant actions in …

Ketamine: differential neurophysiological dynamics in functional networks in the rat brain

A Ahnaou, H Huysmans, R Biermans… - Translational …, 2017 - nature.com
Recently, the N-methyl-d-aspartate-receptor (NMDAR) antagonist ketamine has emerged as
a fast-onset mechanism to achieve antidepressant activity, whereas its psychomimetic …

A systematic review of the effects of NMDA receptor antagonists on oscillatory activity recorded in vivo

MJ Hunt, S Kasicki - Journal of Psychopharmacology, 2013 - journals.sagepub.com
Distinct frequency bands can be differentiated from neuronal ensemble recordings, such as
local field potentials or electrocorticogram recordings. Recent years have witnessed a rapid …

Differential effects of NMDA antagonists on high frequency and gamma EEG oscillations in a neurodevelopmental model of schizophrenia

KG Phillips, MC Cotel, AP McCarthy, DM Edgar… - …, 2012 - Elsevier
Neuroanatomical, electrophysiological and behavioural abnormalities following timed
prenatal methylazoxymethanol acetate (MAM) treatment in rats model changes observed in …

The neurophysiology of ketamine: an integrative review

R McMillan, SD Muthukumaraswamy - Reviews in the Neurosciences, 2020 - degruyter.com
The drug ketamine has been extensively studied due to its use in anaesthesia, as a model of
psychosis and, most recently, its antidepressant properties. Understanding the physiology of …