An insult to the brain (such as the first seizure) causes excitotoxicity, neuroinflammation, and
production of reactive oxygen/nitrogen species (ROS/RNS). ROS and RNS produced during …

Background Marijuana appears to have anti‐epileptic effects in animals. It is not currently
known if it is effective in patients with epilepsy. Some states in the United States of America …

Temporal lobe epilepsy is prevalent and can be difficult to treat effectively. Granule cell axon
(mossy fiber) sprouting is a common neuropathological finding in patients with mesial …

Traumatic brain injury (TBI) greatly increases the risk for a number of mental health
problems and is one of the most common causes of medically intractable epilepsy in …

Psychiatric disorders frequently occur in patients with epilepsy, but the relationship between
epilepsy and psychopathology is poorly understood. Frequent comorbidities in epilepsy …

Many patients develop temporal lobe epilepsy after trauma, but basic mechanisms
underlying the development of chronic seizures after head injury remain poorly understood …

Aberrant sprouting of granule cell axons (mossy fibers) into the inner molecular layer of the
dentate gyrus was first described nearly 40 years ago in lesion studies designed to evaluate …

Temporal lobe epilepsy (TLE) is a condition characterized by an imbalance between
excitation and inhibition in the temporal lobe. Hallmarks of this change are axon sprouting …

Epilepsy is a serious neurological disorder in human beings and the long-term pathological
events remain largely obscure. We are interested in elucidating long-term brain injury that …

Post-traumatic epilepsy (PTE) is one consequence of traumatic brain injury (TBI). A
prominent cell signaling pathway activated in animal models of both TBI and epilepsy is the …