Despite extensive global efforts in the fight against killer infectious diseases, they still cause
one in four deaths worldwide and are important causes of long-term functional disability …

Macrophages, the major host cells harboring Mycobacterium tuberculosis (M. tb), are a
heterogeneous cell type depending on their tissue of origin and host they are derived from …

The central pathogen-immune interface in tuberculosis is the granuloma, a complex host
immune structure that dictates infection trajectory and physiology. Granuloma macrophages …

Genome-wide association studies (GWAS) of chronic periodontitis (CP) defined by clinical
criteria alone have had modest success to-date. Here, we refine the CP phenotype by …

Simple Summary Glioblastoma multiforme is a brain tumor with a very unfavorable
prognosis, where the vast majority of patients do not survive a year after diagnosis. One line …

Abstract Leukotriene B4 (LTB4) is a major type of lipid mediator that is rapidly generated
from arachidonic acid through sequential action of 5-lipoxygenase (5-LO), 5-lipoxygenase …

Tuberculosis (TB) remains an eminent global burden with one third of the world's population
latently infected with Mycobacterium tuberculosis (M. tb). Individuals with compromised …

Towards host-directed therapies for tuberculosis | Nature Reviews Drug Discovery Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Zebrafish has earned its place among animal models of tuberculosis. Its natural pathogen,
Mycobacterium marinum, shares major virulence factors with the human pathogen …

Efficient diagnosis of tuberculosis (TB) is met with multiple challenges, calling for a shift of
focus from pathogen-centric diagnostics towards identification of host-based multi-marker …