Although heterogeneity of FAP+ Cancer-Associated Fibroblasts (CAF) has been described
in breast cancer, their plasticity and spatial distribution remain poorly understood. Here, we …

A comprehensive understanding of tumor heterogeneity, tumor microenvironment and the
mechanisms of drug resistance is fundamental to advancing breast cancer research. While …

High heterogeneity and complex interactions of malignant cells in breast cancer has been
recognized as a driver of cancer progression and therapeutic failure. However, complete …

Background: Breast squamous cell carcinoma (SCC) is an uncommon and highly
aggressive variant of metaplastic breast cancer. Despite its rarity, there is currently no …

Recent advances in multi-modal algorithms have driven and been driven by the increasing
availability of large image-text datasets, leading to significant strides in various fields …

Retinoblastoma (RB) represents one of the most prevalent intraocular cancers in children.
Understanding the tumor heterogeneity in RB is important to design better targeted …

Single-cell RNA sequencing (scRNA-seq) has been invaluable in advancing our
understanding of various cancers, including breast cancer. The extensive analysis of scRNA …

Background Discoidin domain receptor 1 (DDR1) is overexpressed in many cancers and is
a potential therapeutic target. DDR1 is implicated in immune exclusion and collagen …

Localizing multiple RNA molecules simultaneously in intact tissues and organs is valuable
for gaining insights into possible gene-regulatory interactions underlying cell differentiation …

Spatially resolved transcriptomics (SRT) is poised to advance our understanding of cellular
organization within complex tissues under various physiological and pathological conditions …